Gastroentero-histopathology Studies of Synthesized Naproxen Esters in Young Healthy Sprague-Dawley Rat Model

Abstract

Naproxen and its synthesized esters namely naproxen methyl ester, C₁₅H₁₆O₃ (compound 1), ethyl ester, C₁₆H₁₇O₃ (compound 2) and isopropyl ester, C₁₇H₂₀O₃ (compound 3) were subjected to NSAID induced gastro-ulcergenecity studies on young, healthy male rat model. Rats (Rattus novergicus: Sprague-Dawley strain) of 2-months old weighing 95105 g were administered with naproxen (10 mg/kg b.w.) compound 1 (10.609 mg/kg b.w.), compound 2 (11.217 mg/kg b.w.) and compound 3 (11.826 mg/kg b.w.) twice daily for 4.5 days. The naproxen esters appeared to induce significantly less GI injury and bleeding both in microscopic and macroscopic examinations. This study can be a basis of reference for further acute, chronic or subchronic toxicity studies in various in-vivo models.

Dhaka Univ. J. Pharm. Sci. 14(1): 49-53, 2015 (June)