Design and Development of Bi-layered Sustained Release Azithromycin Tablets

Authors

  • Muhammad Rashedul Islam Department of Pharmaceutical Technology, University of Dhaka, Dhaka-1000
  • Md Mizanur Rahman Moghal Department of Pharmacy, MawlanaBhashani Science and Technology University, Santosh, Tangail-1902
  • FM Shah Noman Ul Bari Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814
  • Elias Al Mamun Department of Pharmaceutical Technology, University of Dhaka, Dhaka-1000

DOI:

https://doi.org/10.3329/dujps.v15i2.30942

Keywords:

Azithromycin, bilayer tablet, HPMC, Carbopol, sustained release

Abstract

The objective of the current study was to develop a bilayer tablet of Azithromycin containing both immediate and sustained layer and evaluate the effect of formulation variables on drug release. Thirty different formulations (F-1 to F-30) were prepared by direct compression. When the fraction of polymer was increased from 5.55% to 10%, the rate of drug release was found to be slower. Maximum release of Azithromycin was from F-11 (within 8 hours), which contained 50 mg (5.55%) of HPMC 50 cps. Slowest release was observed from F-30 containing 90 mg (10%) of Carbopol 974 P. The IR spectral analysis revealed that all rate regarding agents and excipients used in this study are compatible with the active Azithromycin.

Dhaka Univ. J. Pharm. Sci. 15(2): 227-234, 2016 (December)

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Author Biography

Muhammad Rashedul Islam, Department of Pharmaceutical Technology, University of Dhaka, Dhaka-1000



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Published

2017-01-02

How to Cite

Islam, M. R., Moghal, M. M. R., Bari, F. S. N. U., & Mamun, E. A. (2017). Design and Development of Bi-layered Sustained Release Azithromycin Tablets. Dhaka University Journal of Pharmaceutical Sciences, 15(2), 227–234. https://doi.org/10.3329/dujps.v15i2.30942

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