Effect of Anogeissus leiocarpus Guill and Perr Leaf on Hyperglycaemia and Associated Dyslipidaemia in Alloxan-induced Diabetic Rats

Authors

  • Uwakwe S Onoja Department of Nutrition and Dietetics, University of Nigeria, Nsukka 410001, Enugu State
  • Cynthia C Ugwu Department of Nutrition and Dietetics, University of Nigeria, Nsukka 410001, Enugu State
  • Philip F Uzor Department of Pharmaceutical and Medicinal Chemistry, University of Nigeria, Nsukka 410001, Enugu State
  • Innocent E Nweze Department of Microbiology, University of Nigeria, Nsukka 410001, Enugu State
  • Edwin O Omeje Department of Pharmaceutical and Medicinal Chemistry, University of Nigeria, Nsukka 410001, Enugu State
  • Petra O Nnamani Department of Pharmaceutics, University of Nigeria, Nsukka 410001, Enugu State
  • Ekere Nwachukwu Department of Pure and Applied Chemistry, University of Nigeria, Nsukka 410001, Enugu State
  • Ivoke Njoku Department of Zoology and Environmental Biology, University of Nigeria, Nsukka 410001, Enugu State
  • Eyo J Effiong Department of Zoology and Environmental Biology, University of Nigeria, Nsukka 410001, Enugu State

DOI:

https://doi.org/10.3329/dujps.v17i1.37120

Keywords:

Anogeissus leiocarpus, antidiabetic, diabetes, hyperglyceamia, hypolipidemia

Abstract

People living with diabetes mellitus across the world are expected to rise to 592 million by 2035 and the pandemic disease is worst in the developing countries like Nigeria, where the cost of treating/managing diabetes mellitus is relatively out of the reach of many diabetic patients. The study investigated the effect of Anogeissus leiocarpus Guill and Perr ethanolic leaf extract on blood glucose and other biochemical indices in alloxan-induced diabetic adult male Wistar albino rats. Diabetes mellitus was induced in overnight-fasted rats by a single intraperitoneal injection of alloxan monohydrate (150 mg/kg body weight). Diabetic rats were then treated with the extract for 14 days. Blood glucose, lipid profile and liver glycogen levels were determined. After the treatment with the extract, the fasting blood glucose levels significantly reduced (p < 0.05) in treated diabetic rats (62.2 ± 18.4 mg/dl) compared to untreated diabetic rats (73.8± 8.2 mg/dl). There was also significant (p < 0.05) reduction in the hyperlipidemic parameters. The results revealed that A. leiocarpus ethanolic extract has antidiabetic and hypolipidemic effects in alloxan-induced diabetic rats.

Dhaka Univ. J. Pharm. Sci. 17(1): 65-72, 2018 (June)

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Published

2018-06-24

How to Cite

Onoja, U. S., Ugwu, C. C., Uzor, P. F., Nweze, I. E., Omeje, E. O., Nnamani, P. O., Nwachukwu, E., Njoku, I., & Effiong, E. J. (2018). Effect of Anogeissus leiocarpus Guill and Perr Leaf on Hyperglycaemia and Associated Dyslipidaemia in Alloxan-induced Diabetic Rats. Dhaka University Journal of Pharmaceutical Sciences, 17(1), 65–72. https://doi.org/10.3329/dujps.v17i1.37120

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