Study of Bioactivities of Holarrhena pubescence Growing in Bangladesh

Authors

  • AK Lutful Kabir Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Mst Marium Begum Department of Pharmacy, East West University, Aftabnagar, Dhaka-1212
  • Tahiya Islam Department of Biomedical Science, Universiti Putra Malaysia, 43400 UPM, Serdang Darul Ehsan

DOI:

https://doi.org/10.3329/dujps.v17i1.37129

Keywords:

Holarrhena pubescence, Anti-diabetic, Analgesic, Anti-inflammatory, Anti-diarrheal

Abstract

The stem bark of Holarrhena pubescence was tested for anti-diabetic, analgesic, anti-inflammatory and antidiarrheal activities. After 1, 4 and 12 weeks of treatment protocol in alloxan-induced diabetic rats, it showed very negligible reduction of blood glucose level. In 12 weeks treatment protocol H. pubescence demonstrated that, the extract at 300 and 600 mg/kg bw can reduce blood glucose level by 3 and 4 mmol/l, respectively. Bark extract possessed strong analgesic, anti-diarrheal and mild anti-inflammatory activities. A dose of 600-mg/kg showed 69.50% (p<0.05) of writhing inhibition compared to indomethacin (73.76%) for acetic acid-induced analgesic method. In formalin-induced anti-nociception, the extract at 300 and 600 mg/kg bw showed dose dependent antinociception (67.42% and 69.007%, respectively, p < 0.05). The anti-diarrheal study demonstrated significant antidiarrheal potential in a dose dependent manner as demonstrated by reduction of defecation by 64.92% and 71.43%, for 300- and 600-mg/kg bw, respectively.

Dhaka Univ. J. Pharm. Sci. 17(1): 131-137, 2018 (June)

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Published

2018-06-24

How to Cite

Kabir, A. L., Begum, M. M., & Islam, T. (2018). Study of Bioactivities of Holarrhena pubescence Growing in Bangladesh. Dhaka University Journal of Pharmaceutical Sciences, 17(1), 131–137. https://doi.org/10.3329/dujps.v17i1.37129

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