Study of Release-Retardant Polymers in Formulation Development of Cinnarizine-HCl Sustained-release Oral Suspension Using Raft Technology: Study of Release-Retardant Polymers in Formulation

Tabinda Islam; Nusrat Hossain; Mohsina Rahman; Sadia Shabnam; Eyasmin Chowdhury; Syeda Tahsin Nahar; Zarin Tasnim Gias; Hasan Mahmud Reza

doi:10.3329/dujps.v19i1.47814

Authors

Tabinda Islam Department of Pharmaceutical Sciences, School of Health and Life Sciences North South University, Plot-15, Block-B, Bashundhara, Dhaka-1229, Bangladesh
Nusrat Hossain Department of Pharmaceutical Sciences, School of Health and Life Sciences North South University, Plot-15, Block-B, Bashundhara, Dhaka-1229, Bangladesh
Mohsina Rahman Department of Pharmaceutical Sciences, School of Health and Life Sciences North South University, Plot-15, Block-B, Bashundhara, Dhaka-1229, Bangladesh
Sadia Shabnam Department of Pharmaceutical Sciences, School of Health and Life Sciences North South University, Plot-15, Block-B, Bashundhara, Dhaka-1229, Bangladesh
Eyasmin Chowdhury Department of Pharmaceutical Sciences, School of Health and Life Sciences North South University, Plot-15, Block-B, Bashundhara, Dhaka-1229, Bangladesh
Syeda Tahsin Nahar Department of Pharmaceutical Sciences, School of Health and Life Sciences North South University, Plot-15, Block-B, Bashundhara, Dhaka-1229, Bangladesh
Zarin Tasnim Gias Department of Pharmaceutical Sciences, School of Health and Life Sciences North South University, Plot-15, Block-B, Bashundhara, Dhaka-1229, Bangladesh
Hasan Mahmud Reza Department of Pharmaceutical Sciences, School of Health and Life Sciences North South University, Plot-15, Block-B, Bashundhara, Dhaka-1229, Bangladesh

DOI:

https://doi.org/10.3329/dujps.v19i1.47814

Keywords:

Cinnarizine-HCl, raft-forming method, sustained-release drug delivery, in-vitro evaluation, dissolution study.

Abstract

The main objective of this research was to develop a sustained-release suspension of cinnarizine hydrochloride using raft-forming technique. This innovative approach has been utilized to formulate a series of suspension formulations using hydroxypropyl cellulose (HPC) as a release-retardant polymeric agent. Cinnarizine sustained-release suspensions were prepared by physical mixing method with varying concentrations and combinations of HPC, sodium citrate, sodium saccharin, calcium carbonate, sodium alginate, methyl hydroxybenzoate and propyl hydroxybenzoate. The formulations were subjected for determination of floating time, floating lag time, weight of the raft, physical appearance and in-vitro dissolution. The dissolution was conducted through USP apparatus 2 (paddle type) in 0.1N hydrochloric acid medium having pH 1.2. The key findings of the study demonstrate that a stable sustained-release suspension of cinnarizine can be formulated using raft-forming approach for increased bioavailability and patient-convenience.

Dhaka Univ. J. Pharm. Sci. 19(1): 15-24, 2020 (June)

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Study of Release-Retardant Polymers in Formulation Development of Cinnarizine-HCl Sustained-release Oral Suspension Using Raft Technology