In vitro Antimicrobial Activity of Some Synthetic Indolium Chloride Derivatives

Arifa Akther; Mohammad Rashedul Haque; Mohammad A Rashid; Md Wahab Khan

doi:10.3329/dujps.v19i2.50628

In vitro Antimicrobial Activity of Some Synthetic Indolium Chloride Derivatives

Authors

Arifa Akther Department of Chemistry, Bangladesh University of Engineering and Technology Dhaka-1000, Bangladesh
Mohammad Rashedul Haque Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka-1000, Bangladesh
Mohammad A Rashid Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka-1000, Bangladesh
Md Wahab Khan Department of Chemistry, Bangladesh University of Engineering and Technology Dhaka-1000, Bangladesh

DOI:

https://doi.org/10.3329/dujps.v19i2.50628

Keywords:

N-acetyl-2-acetylindoliumchloride, antimicrobial assay, disc diffusion

Abstract

A total of eight compounds including four starting materials and four indolium chloride derivatives were tested against Gram positive and Gram negative bacterial and fungal strains. Among them, N-acetyl-2- acetylindoliumchloride (8) exhibited significant antimicrobial activity at a concentration of 200 μg/disc, while the Nacetyl- 2-benzoylindoliumchloride (9) showed moderate activity at 400 μg/disc. At the same time, N-acetyl-2- anisoylindoliumchloride (10) and N-acetyl-2-tolylindoliumchloride (11) demonstrated weak antimicrobial activity.

Dhaka Univ. J. Pharm. Sci. 19(2): 133-137, 2020 (December)

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Published

2020-12-10

How to Cite

Akther, A., Haque, M. R., Rashid, M. A., & Khan, M. W. (2020). In vitro Antimicrobial Activity of Some Synthetic Indolium Chloride Derivatives. Dhaka University Journal of Pharmaceutical Sciences, 19(2), 133–137. https://doi.org/10.3329/dujps.v19i2.50628