Phytochemical and Biological investigations of <i>Phoenix paludosa</i> Roxb.

Abstract

Lupeol (1), epilupeol (2) and β-sitosterol (3) were isolated from the n-hexane and the carbon
tetrachloride soluble fraction of a methanol extract of the leaves of Phoenix paludosa Roxb. The n-hexane, carbon
tetrachloride and chloroform soluble materials from the concentrated methanol extract were subjected to
antimicrobial screening and brine shrimp lethality bioassay. All of the partitionates showed insensitivity to microbial
growth, while the n-hexane, chloroform and methanol soluble fractions showed significant cytotoxicity having LC₅₀
2.17 μg/ml, 2.77 μg/ml and 2.46 μg/ml, respectively. This is the first report of isolation of the compounds 1-3 and
bioactivities of P. paludosa.

Key words: Phoenix paludosa; Aracaceae; Lupeol; Epi-Lupeol; β-sitosterol; Brine shrimp lethality bioassay;
Antimicrobial.

DOI: 10.3329/dujps.v8i1.5329

Dhaka Univ. J. Pharm. Sci. 8(1): 7-10, 2009 (June)