Evaluation of Dissolution Behavior of Cefuroxime Axetil as Affected by Polymeric Interaction Using Mixture Design Experiment

Authors

  • Khandokar Sadique Faisal Department of Pharmacy, University of Asia Pacific, Dhaka-1215, Bangladesh
  • Mohiuddin Ahmed Bhuiyan Department of Pharmacy, University of Asia Pacific, Dhaka-1215, Bangladesh
  • Md Elias Al Mamun Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka Dhaka-1000, Bangladesh

DOI:

https://doi.org/10.3329/dujps.v20i3.59797

Keywords:

Solid Dispersion, Cefuroxime Axetil, Simplex Mixture Design, Polymeric Interaction

Abstract

The objective of this project was to improve the solubility of poorly water soluble drugs, namely cefuroxime axetil by formulating solid dispersions with hydrophilic polymer. Hydroxypropyl methyl cellulose (HPMC), polyvinyl pyrrolidine (PVP) and polyethylene glycol (PEG) were used as polymeric carriers for the preparation of solid dispersion. Solid dispersions were prepared by the solvent extraction method. Interaction effect of HPMC, PVP and PEG was investigated using a simplex mixture design. A fitted mathematical model was used to express each response as a function of the proportion of the blend components that are able to empirically predict the response to any blend of combination of the components. The synergistic interaction effect of the ternary HPMC: PVP: PEG blend was shown to be strongest among the experimental blends. Nevertheless, an antagonistic interaction effect becomes significant as the HPMC proportion increases in the blends. The study revealed that a mixture design could be a valuable tool in better elucidating and predicting the effects on dissolution beyond the conventional one component blend.

Dhaka Univ. J. Pharm. Sci. 20(3): 317-324, 2022 (June) Centennial Special Issue

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Published

2022-06-09

How to Cite

Faisal, K. S., Bhuiyan, M. A. ., & Al Mamun, M. E. . (2022). Evaluation of Dissolution Behavior of Cefuroxime Axetil as Affected by Polymeric Interaction Using Mixture Design Experiment. Dhaka University Journal of Pharmaceutical Sciences, 20(3), 317–324. https://doi.org/10.3329/dujps.v20i3.59797