Evaluation of Dissolution Behavior of Cefuroxime Axetil as Affected by Polymeric Interaction Using Mixture Design Experiment

Abstract

The objective of this project was to improve the solubility of poorly water soluble drugs, namely cefuroxime axetil by formulating solid dispersions with hydrophilic polymer. Hydroxypropyl methyl cellulose (HPMC), polyvinyl pyrrolidine (PVP) and polyethylene glycol (PEG) were used as polymeric carriers for the preparation of solid dispersion. Solid dispersions were prepared by the solvent extraction method. Interaction effect of HPMC, PVP and PEG was investigated using a simplex mixture design. A fitted mathematical model was used to express each response as a function of the proportion of the blend components that are able to empirically predict the response to any blend of combination of the components. The synergistic interaction effect of the ternary HPMC: PVP: PEG blend was shown to be strongest among the experimental blends. Nevertheless, an antagonistic interaction effect becomes significant as the HPMC proportion increases in the blends. The study revealed that a mixture design could be a valuable tool in better elucidating and predicting the effects on dissolution beyond the conventional one component blend.

Dhaka Univ. J. Pharm. Sci. 20(3): 317-324, 2022 (June) Centennial Special Issue