Evaluation of Sorghum bicolor (L.) Moench on the Reduction of Creatinine Levels and Its Antioxidant Properties In vitro

Authors

  • Ogochukwu Immaculate Obika Department of Pharmacognosy, Faculty of Pharmacy, University of Lagos, Nigeria
  • Aminat Asabi Oyawaluja Department of Pharmacognosy, Faculty of Pharmacy, University of Lagos, Nigeria
  • Joseph O Oiseoghaede Department of Pharmacognosy, Faculty of Pharmacy, University of Lagos, Nigeria
  • Olukemi Abiodun Odukoya Department of Pharmacognosy, Faculty of Pharmacy, University of Lagos, Nigeria
  • Ngozi Afulenu Obika Ndiri Department of Nursing Science, Faculty of Basic Medical Science, Rivers State University Nigeria

DOI:

https://doi.org/10.3329/dujps.v21i2.63117

Keywords:

Sorghum bicolor, creatinine, antioxidant, reno-protective, kidney, VLC, in-vitro, chromatography, DPPH

Abstract

The study investigated the effect of Sorghum bicolor (L.) Moench extract on the renal activity of both normal and ailing patients. Phytochemical analysis, antioxidant activity, vacuum liquid chromatography and TLC were carried out. The creatinine reduction ability was analyzed using Jaffe’s method for clean-catch spot urine samples of normal, diabetic and hypertensive patients. S. bicolor showed strong antioxidant activity with an IC50 value of 52.17 μg/ml, compared to the standard vitamin C with an IC50 value of 40.59 μg/ml. Statistical analysis (ANOVA) result showed a significant difference between the patients’ urine (rows) (p-value = 2.77×10–08) and a significant difference between the dose treatments (columns) (p-value = 8.38×10–14). Whilst different fractions of S. bicolor at different concentrations showed varying effects on the creatinine concentration, it reduced creatinine level in low doses and has antioxidant properties.

Dhaka Univ. J. Pharm. Sci. 21(2): 165-172, 2022 (December)

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Published

2022-12-28

How to Cite

Obika, O. I. ., Oyawaluja, A. A. ., Oiseoghaede, J. O., Odukoya, O. A. ., & Ndiri, N. A. O. (2022). Evaluation of Sorghum bicolor (L.) Moench on the Reduction of Creatinine Levels and Its Antioxidant Properties In vitro. Dhaka University Journal of Pharmaceutical Sciences, 21(2), 165–172. https://doi.org/10.3329/dujps.v21i2.63117

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