@article{Akter_Saha_Rahman_2015, title={Gastroentero-histopathology Studies of Synthesized Naproxen Esters in Young Healthy Sprague-Dawley Rat Model}, volume={14}, url={https://banglajol.info/index.php/JPharma/article/view/23735}, DOI={10.3329/dujps.v14i1.23735}, abstractNote={<p>Naproxen and its synthesized esters namely naproxen methyl ester, C<sub>15</sub>H<sub>16</sub>O<sub>3</sub> (compound 1), ethyl ester, C<sub>16</sub>H<sub>17</sub>O<sub>3</sub> (compound 2) and isopropyl ester, C<sub>17</sub>H<sub>20</sub>O<sub>3</sub> (compound 3) were subjected to NSAID induced gastro-ulcergenecity studies on young, healthy male rat model. Rats (Rattus novergicus: Sprague-Dawley strain) of 2-months old weighing 95–105 g were administered with naproxen (10 mg/kg b.w.) compound 1 (10.609 mg/kg b.w.), compound 2 (11.217 mg/kg b.w.) and compound 3 (11.826 mg/kg b.w.) twice daily for 4.5 days. The naproxen esters appeared to induce significantly less GI injury and bleeding both in microscopic and macroscopic examinations. This study can be a basis of reference for further acute, chronic or subchronic toxicity studies in various in-vivo models.</p><p>Dhaka Univ. J. Pharm. Sci. 14(1): 49-53, 2015 (June)</p>}, number={1}, journal={Dhaka University Journal of Pharmaceutical Sciences}, author={Akter, Mansura and Saha, Sajal Kumar and Rahman, SM Abdur}, year={2015}, month={Jun.}, pages={49–53} }