TY - JOUR AU - Islam, Ashiqul AU - Haider, Syed Shabbir AU - Reza, Md Selim PY - 2012/09/04 Y2 - 2024/03/28 TI - Formulation and Evaluation of Orodispersible Tablet of Domperidone JF - Dhaka University Journal of Pharmaceutical Sciences JA - Dhaka Univ. J. Pharm. Sci VL - 10 IS - 2 SE - Articles DO - 10.3329/dujps.v10i2.11791 UR - https://banglajol.info/index.php/JPharma/article/view/11791 SP - 117-122 AB - <p>The aim of the present study was to develop and evaluate orodispersible tablets of domperidone by  direct compression method. Sodium starch glycolate ( SCG ), Kollidone CLSF and sodium bicarbonate were used as  disintegrants to achieve the desired disintegration time required for orodispersible tablets. To mask the bitter taste of  drug, impart sweetness and to offer a better feeling in mouth, saccharin sodium, aspartame, citric acid, menthol and  lemon flavor were also added. Mannitol and lactose were used as sugar based multifunctional diluents. The prepared  tablets were evaluated for their physical (hardness, friability, weight variation), organoleptic (taste, mouth-feel, color)  and functional (disintegration time) properties and for the drug content. The excipients were used in various  concentrations in order to optimize the desired properties. SCG and Kollidone CLSF, used in 5.5% and 4%  respectively, gave satisfactory disintegration time using BP instrument and within the mouth. Combination of  saccharin sodium (1.5%) and aspartame (3%) along with mannitol (40%) and other excipients effectively masked the  bitterness and provided satisfactory sweetness level. Incorporation of 0.05% menthol provided excellent mouth  feeling as assessed by a panel of volunteers. Hardness and friability values were also optimized in the formulations to  produce tablets of acceptable physical stability and mechanical strength. Weight variation and drug content of all  formulations fully complied with the official specifications.</p> <p> </p> <p>DOI: <a href="http://dx.doi.org/10.3329/dujps.v10i2.11791">http://dx.doi.org/10.3329/dujps.v10i2.11791</a></p> <p> </p> <p>Dhaka Univ. J. Pharm. Sci. <strong>10</strong>(2): 117-122, 2011 (December)</p> <p> </p> <p> </p> ER -