TY - JOUR AU - Swamy, PV AU - Shahidulla, SM AU - Shirsand, SB AU - Hiremath, SN AU - Ali, Md Younus PY - 2008/10/07 Y2 - 2024/03/28 TI - Orodispersible Tablets of Carbamazepine Prepared by Direct Compression Method Using 32 Full Factorial Design JF - Dhaka University Journal of Pharmaceutical Sciences JA - Dhaka Univ. J. Pharm. Sci VL - 7 IS - 1 SE - Articles DO - 10.3329/dujps.v7i1.1199 UR - https://banglajol.info/index.php/JPharma/article/view/1199 SP - 1-5 AB - <p>Orodispersible tablets of carbamazepine were prepared with a view to enhance patient compliance by direct compression method using 3² full factorial design. Crospovidone (2-10% w/w) was used as superdisintegrant and microcrystallinecellulose (0-30% w/w) was used as diluent, along with directly compressible mannitol to enhance mouth feel. The tablets were evaluated for hardness, friability, thickness, drug content uniformity, <em>in vitro</em> dispersion time, wetting time and water absorption ratio. Based on <em>in vitro </em>dispersion time (approximately 10 s); the formulation containing 2% w/w crospovidone and 30%w/w microcrystallinecellulose was found to be promising and tested for in vitro drug release pattern (in pH 6.8 phosphate buffer), short-term stability (at 40º/75 % RH for 3 w) and drug-excipient interaction. This formulation showed four-fold faster drug release (t25%) compared to the conventional commercial tablet formulation. Short-term stability studies on the formulation indicated that there are no significant changes in drug content and in vitro dispersion time (p < 0.05).</p><p><strong>Key words:</strong> Orodispersible tablets, carbamazepine, crospovidone, micro crystallinecellulose, 3² full factorial design</p><p>DOI = 10.3329/dujps.v7i1.1199</p><p>Dhaka Univ. J. Pharm. Sci. 7(1): 1-5, 2008 (June)</p> ER -