TY - JOUR AU - Momoh, MA AU - Kenechukwu, FC AU - Gwarzo, MS AU - Builders, PF PY - 2015/06/18 Y2 - 2024/03/29 TI - Formulation and Evaluation of Ibuprofen Loaded Lipospheres for Effective Oral Drug Delivery JF - Dhaka University Journal of Pharmaceutical Sciences JA - Dhaka Univ. J. Pharm. Sci VL - 14 IS - 1 SE - Articles DO - 10.3329/dujps.v14i1.23730 UR - https://banglajol.info/index.php/JPharma/article/view/23730 SP - 17-27 AB - <p>Ibuprofen (IBU) is an anti-inflammatory drug characterized by low solubility and bioavailabilty. This study was to develop IBU-liposphere and investigated for <em>in vitro </em>and <em>in vivo </em>performance. IBU free base was incorporated into lipospheres based on micronized beeswax and Phospholipon® 90H in the ratio of (1:3), via hot emulsification. IBU-loaded lipospheres were characterized based on morphology, encapsulation efficiency (EE%), and <em>in vitro </em>drug release. Analgesic, anti-inflammatory activities and the pharmacokinetics were similarly evaluated. Minimum and maximum encapsulation efficiency (EE%) of 89.4 and 97.9% were obtained for lipospheres A1 and A3, respectively. Stable, spherical and smooth lipospheres of size range 101 ± 0.30 to 178 ± 0.30 ?m were obtained. Minimum and maximum release of 75 and 96.9% were obtained for A1 and A3, respectively. Significant (p&lt;0.005) analgesic and anti-inflammatory activities were achieved with prolong plasma concentration. IBU-lipospheres based on beeswax and phospholipid could be explored as an alternative drug delivery system.</p><p>Dhaka Univ. J. Pharm. Sci. 14(1): 17-27, 2015 (June)</p> ER -