TY - JOUR AU - Hossain, Md Mokaram AU - Jalil, Reza ul AU - Rashid, Mohammad A PY - 2018/12/04 Y2 - 2024/03/28 TI - Studies of Degradation Kinetics of a 5-HT3 Antagonist, Ramosetron Hydrochloride: Effects of Temperature JF - Dhaka University Journal of Pharmaceutical Sciences JA - Dhaka Univ. J. Pharm. Sci VL - 17 IS - 2 SE - Articles DO - 10.3329/dujps.v17i2.39172 UR - https://banglajol.info/index.php/JPharma/article/view/39172 SP - 167-173 AB - <p>Ramosetron hydrochloride is the hydrochloride salt of ramosetron, a selective serotonin (5-HT3) receptor antagonist with potential antiemetic activity. Upon administration, ramosetron selectively binds to and blocks the activity of 5-HT subtype 3 (5-HT<sub>3</sub>) receptors located in the vagus nerve terminal and the vomiting center of central nervous system (CNS), suppressing chemotherapy-induced nausea and vomiting. Degradation of Ramosetron HCl was conducted with 0.1N NaOH at 60<sup>°</sup>C, 70<sup>°</sup>C and 80<sup>°</sup>C to study the reaction kinetics. The reaction rate constants (k) for degradation at 60<sup>°</sup>C, 70<sup>°</sup>C and 80<sup>°</sup>C were -2.2680 molL<sup>-1</sup>s<sup>-1</sup> , -3.3714 molL<sup>-1</sup>s<sup>-1</sup> and -5.3686 molL<sup>-1</sup>s<sup>-1</sup> for zero order and -1.05 x 10<sup>-2</sup>s<sup>-1</sup>, -1.60 x 10<sup>-2</sup>s<sup>-1</sup> and -2.70 x 10<sup>-2</sup>s<sup>-1</sup> for first order kinetics, respectively. The activation energy of Ramosetron HCl was found as 10.05 kcalmol<sup>-1</sup> by using Arrhenius equation.</p><p>Dhaka Univ. J. Pharm. Sci. 17(2): 167-173, 2018 (December)</p> ER -