Journal of Rangpur Medical College <p>Published by the Rangpur Medical College, Rangpur<strong>. </strong>Full-text articles available.</p> <p><img class="alignright" src="" alt="image" width="88" height="31" /><br />Articles in the Journal of Rangpur Medical College are Open Access articles published under the Creative Commons CC BY-NC-ND License <span class="cc-license-title"><a href="" target="_blank" rel="noopener">Attribution-NonCommercial-NoDerivatives 4.0 International License</a></span></p> Rangpur Medical College, Rangpur en-US Journal of Rangpur Medical College 2618-0413 Isoniazid-induced Encephalopathy in a Patient with Pott’s Disease with Chronic Kidney Disease: A Case Report <p>We report an isoniazid-induced encephalopathy in a man with chronic renal failure. Drug-induced encephalopathy is a common side effect of many drugs. Isoniazid (INH), a first-line drug for tuberculosis, can cause encephalopathy in patients with chronic kidney disease (CKD). For Pott's disease of the thoracic spine, he received rifampicin, INH, pyrazinamide, and ethambutol with pyridoxine and prednisolone. But the patient is free of pyridoxine for two and a half months. Subsequently, after treatment, the patient experienced recurrent episodes of altered consciousness, irrelevant conversations, and disorientation. After ruling out other causes, isoniazid-induced encephalopathy was suspected and confirmed by improvement of symptoms after discontinuation of high-dose isoniazid and pyridoxine.</p> <p>J Rang Med Col. March 2023; Vol. 8, No. 1:72-75</p> Md Helal Miah Md Ahad Bakas Md Kamal Hossein Tahmina Begum Md Shafiul Alam Md Jahangir Kabir Abu Said Md Rahenur Mondol Md Ruhul Amin Sarkar Md Mahfuj Ul Anwar Shah Md Sarwer Jahan Md Mahfuzer Rahman Copyright (c) 2023 Journal of Rangpur Medical College 2023-04-04 2023-04-04 8 1 72 75 10.3329/jrpmc.v8i1.65066 Prevalence of Microalbuminuria and its Association with Left Ventricular Hypertrophy (LVH), Ischemic Heart Disease (IHD), Retinopathy, and Stroke in Hypertension <p><strong>Background: </strong>Hypertension is a growing issue of public health problem of the adult population in both developed as well as developing world, is a serious medical condition that significantly increases the risks of heart, brain, kidney, and other diseases. There is a strong association between Microalbuminuria (MA) and hypertension. Microalbuminuria (MA) is the independent risk factor for developing cardiovascular and cerebrovascular morbidity and mortality in hypertension, suggesting that microalbuminuria (MA) could be a useful marker to assess the risk management of cardiovascular disease and renal disease.</p> <p><strong>Objective: </strong>To assess the frequency of microalbuminuria in hypertension and to evaluate its association with left ventricular hypertrophy (LVH), ischemic heart disease (IHD), retinopathy, and stroke.</p> <p><strong>Methods: </strong>This cross-sectional descriptive study was conducted at the Hypertension &amp; Research Centre, Rangpur from January 2010 to January 2012. A total of 75 hypertensives without diabetes mellitus and/or other conditions causing microalbuminuria were purposively selected. Urine albumin was assessed and microalbuminuria was defined as albumin excretion between 20-200 microg/min. The relationship of microalbuminuria with the duration, severity, body mass index (BMI), lipid profile, and target organ damage (TOD) like left ventricular hypertrophy (LVH), ischemic heart disease (IHD), hypertensive retinopathy, and stroke was assessed by univariate analysis.</p> <p><strong>Results: </strong>The patients were in between the age of 20-79 years with mean age of 52.98±12.2. Out of 75 subjects, 47 (62.7%) patients were male and 28 (37.3%) were female. Of the study group, 53 patients had stage 1 and 22 patients had stage 2 hypertension. Among the stage-1 hypertensive (53), 5 patients had microalbuminuria and 6 patients had microalbuminuria in stage-2 hypertensive (22) (p=0.047). Microalbuminuria was significantly higher in those with longer duration and greater severity of hypertension (p =0.039). Older age (p =0.008), and adverse lipid profile (p =0.003) were the other identifiable risk factors for microalbuminuria. Stroke (OR=9.77), echocardiography-proven LVH (OR=6.25), ECG and/or echocardiographyproven IHD (OR=8.71) and hypertensive retinopathy (OR=4.14) were significantly higher in those with microalbuminuria.</p> <p><strong>Conclusion: </strong>The prevalence of microalbuminuria in hypertensive subjects is high and patients with microalbuminuria have high odds of developing TOD like stroke, LVH, IHD, and hypertensive retinopathy. So the early detection of microalbuminuria in hypertensive as well as prompt treatment may reduce the burden of TOD.</p> <p>J Rang Med Col. March 2023; Vol. 8, No. 2:3-10</p> Abu Said Md Rahenur Mondol Tanzina Zaman Md Mahfuj Ul Anwar Md Helal Miah Md Al Fatah Al Adiluzzaman Akter Banu Shah Md Sarwer Jahan Md Mahfuzer Rahman Copyright (c) 2022 Journal of Rangpur Medical College 2023-04-04 2023-04-04 8 1 3 10 10.3329/jrpmc.v8i1.65027 Knowledge, Attitude, and Practice of Reproductive-Aged Bangladeshi Adult Females with Hypothyroidism <p><strong>Background: </strong>Successful treatment in patients with hypothyroidism depends on adequate knowledge, a positive attitude, and appropriate practices. Deficiency in any domain may lead to the persistence of symptoms, difficulty issues in pregnancy, as well as adverse effects on offspring in female patients.</p> <p><strong>Objective: </strong>To evaluate the knowledge, attitude, and practice (KAP) of reproductive-aged adult (18 – 45 years) females with hypothyroidism and their associations with current treatment status.</p> <p><strong>Methods: </strong>This cross-sectional questionnaire-based KAP survey was done at seven places across Bangladesh in government hospitals and private chambers among 393 hypothyroid patients [age: 30.0 (25.0-36.0), years, median (IQR)]. Adult females who could read and understand the Bangla language were included. Patients with known dementia, illiterate, severely ill, and unwilling to participate were excluded. The knowledge domain consisted of ten single-best multiple-choice questions (MCQs: 3-4 choices). The attitude domain had five statements with a five-point Likert scale ranging from strongly agree to strongly disagree. The practice domain had also ten single best MCQs (3-5 choices) to assess the patients’ most common practice behaviors. The questionnaire was supplied to each patient and advised to put a tick mark at the appropriate option. Patients’ treatment status was considered by current serum TSH levels (0.4 – 4.0 mIU/mL).</p> <p><strong>Results: </strong>The percent of over-replacement, appropriate replacement, and under-replacement was around 12%, 47%, and 41% of the study population respectively. Around 39% had good knowledge, 78% were highly concerned about thyroid disorders, and only 22% were highly cautious about their practice. Age and educational status might be associated with all three domains.</p> <p><strong>Conclusions: </strong>More than half of the reproductive-aged adult females’ treatment status was inappropriate. Discrepancies among the three domains might be associated with the age and knowledge status of the participants. The study findings will help clinicians to manage patients with hypothyroidism more efficiently.</p> <p>J Rang Med Col. March 2023; Vol. 8, No. 2:11-19</p> Md Shahed Morshed Md Firoj Hossain Satyajit Mallick Md Lutful Kabir Mohaimenul Abedin Md Ahamedul Kabir ATM Zabed Hasan Copyright (c) 2022 Journal of Rangpur Medical College 2023-04-04 2023-04-04 8 1 11 19 10.3329/jrpmc.v8i1.65032 Comparison Between Effects of Ketofol and Fenofol as Sedative in Elective Caesarean Section Under Subarachnoid Anaesthesia <p><strong>Background: </strong>Regional anaesthesia has become an important anaesthetic technique now a days. The use of spinal (subarachnoid) anaesthesia is often limited by the unwillingness of patients to remain awake during surgery. Pharmacologically induced tranquility improves acceptance of regional technique.</p> <p><strong>Objective: </strong>This study compares Ketofol (Ketamine+Propofol) and Fenofol (Fentanyl+ Propofol) in terms of onset and recovery of sedation, haemodynamic effects, respiratory effects and adverse effects of both the drugs during elective Caesarian section under spinal anaesthesia.</p> <p><strong>Methods: </strong>This randomized clinical trial included 60 ASA (American Society of Anaesthesiologists) grade I or II patients between age 20-40 years undergoing elective Caesarean sections under Subarachnoid anaesthesia during the period of January 2022 to June 2022. Patients were randomly allocated to one of two groups: Ketofol group (Group KP, n=30), who received Ketofol in a single dose of 0.5mg/kg (Ketamine- 0.5mg/kg+Propofol-0.5mg/kg) and Fenofol group (Group FP, n=30), who received Fenofol in a single dose of Fentanyl-0.5mcg/kg+Propofol-0.5mg/kg. Spinal anaesthesia was conducted by injecting a hyperbaric solution of 0.5% bupivacaine 3ml through a 25G spinal needle at L3-4 level. All parameters were documented at 5 min intervals until arousal of the patient. The onset of sedation i.e. time from iv (intravenous) injection of Ketofol or Fenofol to closure of eye lids and the arousal time from sedation i.e. time from closing of the eye lids to OAA/S score of 5 (patient is awake clinically) were noted. Any complication during operation was documented. Patient’s satisfaction with the sedation was assessed by the 5 point ‘Likert verbal rating scale.</p> <p><strong>Results: </strong>There was no significant difference of mean blood pressure and mean heart rate between the two groups (P&gt;0.05). Time of onset of sedation was comparable between the two groups (P&gt;0.05). Duration of sedation was significantly less in Fenofol group (p value=&lt;0.001). Significant percentage of patients required oxygen supplementation after sedation with Fenofol due to hypoventilation (66.66% vs 10%, p value &lt;0.001). Incidence of nausea and vomiting was significantly more with Fenofol (46.66% vs 10%, p value &gt;0.001).</p> <p><strong>Conclusion: </strong>The study showed that the arousal time i.e. duration of sedation was significantly more with Ketofol than Fenofol which is beneficial for the patient in single dose technique for sedation. Fenofol was associated with significantly high incidence of nausea, vomiting. Moreover, significantly higher percentage of patients required O<sub>2</sub> supplementation due to hypoventilation during sedation with Fenofol. Thus it is recommended that Ketofol is a better choice than Fenofol for sedation in single dose technique during subarachnoid block for Caesarean section. </p> <p>J Rang Med Col. March 2023; Vol. 8, No. 2:20-26</p> <p> </p> Md Enayet Karim RAM Mustafijur Rashid Mohammad Saleh Akram Reza Ershad Copyright (c) 2022 Journal of Rangpur Medical College 2023-04-04 2023-04-04 8 1 20 26 10.3329/jrpmc.v8i1.65033 Evaluation of Estimated Glomerular Filtration Rate in Obese Male Adults and Its Correlation with BMI <p><strong>Background: </strong>Overweight and obesity has been announced as a global epidemic by The World Health Organization. These conditions have strong associations with renal function impairment.</p> <p><strong>Objectives: </strong>To evaluate the estimated glomerular filtration rate (eGFR) in obese male adults and to observe the correlation of eGFR with body mass index (BMI).</p> <p><strong>Methods: </strong>This cross-sectional analytical study was conducted at the Department of Physiology, Rangpur Medical College, Rangpur. After briefing about objectives, adult males who met the inclusion and exclusion criteria were enrolled in the study by consensus. The study involved 60 people who were divided into two groups: apparently healthy adult males of average weight (Group A) and apparently healthy adult males who were obese (Group B). The subjects were selected from different districts of the city of Rangpur. Their body mass index &amp; serum creatinine were measured. eGFR was calculated by Cockcroft-Gault equation using serum creatinine. For statistical analysis, unpaired t-test and Pearson’s correlation coefficient test were performed as applicable by computer-based SPSS–25.0 for windows. Regarding the interpretation of results, p≤0.05 was accepted as significant.</p> <p><strong>Results: </strong>The mean of estimated glomerular filtration rate was significantly (p≤ 0.001) lower in obese male adults than in normal-weight male adults. This study also found a highly significant (p≤0.05) negative correlation of eGFR (r = -0.317) with body mass index.</p> <p><strong>Conclusion: </strong>eGFR is reduced in obese male adults, and it is negatively correlated with BMI. Regular body mass index screening is recommended as an easy and effective means of assessing body weight.</p> <p>J Rang Med Col. March 2023; Vol. 8, No. 2:27-32</p> Safina Akhter Chandra Rani Sarkar ATM Zoadur Rahim Zahid Copyright (c) 2023 Journal of Rangpur Medical College 2023-04-04 2023-04-04 8 1 27 32 10.3329/jrpmc.v8i1.65034 Sensitivity, Specificity, Predictive Values and Accuracy of clinical diagnosis of Acute Stroke <p><strong>Background: </strong>Stroke is a leading cause of death and disability globally and particularly in low and middle-income countries, and the burden is increasing. To prevent complications and permanent defects in stroke, early diagnosis is the key that can easily obtained by a CT scan of brain. However, quick access to CT scanning is not available in every country and hospital specially in Bangladesh, various clinical findings especially neurological signs and symptoms and risk factors differentiation are helpful in differentiating the types of stroke.</p> <p><strong>Objective: </strong>This study aimed to see the sensitivity, specificity, positive predictive value, negative predictive value and accuracy of clinical diagnosis in the detection of stroke subtype.</p> <p><strong>Methods: </strong>This hospital based cross-sectional comparative study was conducted in Department of Medicine, Rangpur medical college hospital, Rangpur, Bangladesh from January 2010 to December 2011 on three hundred (300) suspected acute stroke patients selected by purposive sampling technique. The clinical diagnosis of type of stroke was made on the basis of mode of presentation, risk factors and signs and confirmed by CT scan of brain within 1 week of attack. Then the clinical diagnosis was compared with the results of CT scan. Statistical analyses related with this study were performed by using of SPSS-19 package program.</p> <p><strong>Results: </strong>Among the 300 patients, 73(24.3%) patients were clinically diagnosed as hemorrhagic stroke and 227(75.6%) patients were as infarctive stroke. Out of 73 clinically diagnosed haemorrhagic stroke patients, CT scan revealed that 61 (83.6%) patients had intracerebral hemorrhage, 5 (6.8%) had infarct. And out of 133 diagnosed ischemic stroke patients, CT scan revealed that 203 (89.4%) patients had infarction, 6 (2.6%) had intracerebral hemorrhage. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of clinical diagnosis of hemorrhagic stroke were 91.0%, 94.8%, 83.6%, 97.4% and 94.0% respectively. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of clinical diagnosis of infarctive stroke were 97.6%, 73.9%, 89.4%, 92.2% and 90.3% respectively.</p> <p><strong>Conclusion: </strong>CT scan of brain remains the gold standard for differential diagnosis, but the availability of CT scan is not always feasible, and it is virtually impossible to submit all stroke patients to CT scan. Adequate knowledge on risk factors, clinical features and initial investigations may contribute to such a differentiation of cerebral infarction from intracerebral hemorrhage with high accuracy where rapid access to Computed Tomography (CT) is lacking.</p> <p>J Rang Med Col. March 2023; Vol. 8, No. 2:33-39</p> Md Mahfuj Ul Anwar Sajeda Afrin Md Shakhawat Hossain Shah Md Sarwer Jahan Md Mahfuzer Rahman Copyright (c) 2023 Journal of Rangpur Medical College 2023-04-04 2023-04-04 8 1 33 39 10.3329/jrpmc.v8i1.65038 Randomized Control Trial of 3% Nebulized Hypertonic Saline in Reducing the Length of Hospital Stay in Children with Bronchiolitis <p><strong>Background: </strong>Bronchiolitis is the most common cause of lower respiratory tract infections within the first 2 years of life. Despite tantalizing efforts, an effective optimized treatment for bronchiolitis still remains elusive. Nebulized hypertonic saline may improve clinical severity scores and reduce length of hospital stay among infants with non-severe acute bronchiolitis.</p> <p><strong>Objective: </strong>The objective of this study was to evaluate efficacy of 3% hypertonic saline in reducing the length of hospital stay in children with bronchiolitis.</p> <p><strong>Method: </strong>This randomized control trial was conducted in the department of Paediatrics, Rangpur Medical College Hospital between July 2018 to June 2020. After acceptance and ethical clearance, 72 infants and young children fulfilling the selection criteria were enrolled into this study. Children were randomly divided into two groups, designed as group–A and group–B. Patients in group A were nebulized with 3% hypertonic saline and group B with normal saline. Patients in each group were nebulized three times 8 hourly during hospital stay. Each group received the same standard supportive measures. Data was analyzed through SPSS (version 23.0) software using chi-square test, student t' test, where applicable. Statistical significance was set as 0.05 level<strong>.</strong></p> <p><strong>Results: </strong>Among the 72 children, 72.22% (26/36) of group A and 58.33% (21/36) of group B were male, with a male female ratio of 1.88:1. Mean age of the children of group A (7.5±1.94 months) was significantly higher than that of group B (5.8±2.01 months) (p=0.032). Baseline clinical characteristics were almost similar, except oxygen saturation (p&lt;0.001) between the two groups. 88.9% (32/36) patients of group A and 41.7% (15/36) from group B recovered and were discharged within 72 hours. After 72 hours, 11.1% (4/36) from group A and 58.3% (21/36) from group B recovered and were discharged (p&lt;0.001). Mean length of hospital stay was shorter in the hypertonic saline group (2.28 ± 0.45 days) than that in the normal saline group (3.72 ±0.45 days).</p> <p><strong>Conclusion: </strong>The length of hospital stay was effectively reduced by 3% nebulized hypertonic saline in children with bronchiolitis.</p> <p>J Rang Med Col. March 2023; Vol. 8, No. 2:40-43</p> Nafisa Zaman Bedanta Majumder Md Mazharul Islam Bikash Kumar Majumder Shahana Afreen Prahlad Kumar Shil Copyright (c) 2023 Journal of Rangpur Medical College 2023-04-04 2023-04-04 8 1 40 43 10.3329/jrpmc.v8i1.65055 Serum Level of Homocysteine, Folate, and Vitamin B12 in Adult Epileptic Patients Under Antiepileptic Therapy <p><strong>Background: </strong>Epilepsy is a medical condition that requires long-term treatment with antiepileptic drugs. Different epidemiological studies revealed an increased risk of atherogenic cardiovascular diseases in patients under antiepileptic therapy. The possible etiologic suggestion is alterations of the serum homocysteine, folate, and vitamin B12 metabolism.</p> <p><strong>Objective: </strong>To evaluate serum homocysteine, folate, and vitamin B12 level in patients under antiepileptic monotherapy.</p> <p><strong>Methods: </strong>This cross-sectional study was conducted in the Department of Biochemistry, Dhaka Medical College from July 2017 to June 2018 through purposive sampling. In this study, forty diagnosed patients under antiepileptic monotherapy and forty age and sex-matched apparently healthy control were selected according to selection criteria, from OPD of the Neurology department, Dhaka medical college hospital.</p> <p><strong>Results: </strong>In patients under antiepileptic therapy, mean (±SD) of serum homocysteine (μmol/L), folate (ng/ml), and vitamin B12 (pg/ml) were 14.15±3.4, 13.61±2.02, 361.78±41.26 respectively. In the healthy control group, serum homocysteine (μmol/L), folate (ng/ml), and vitamin B12 (pg/ml) were 8.78±2.59, 16.71±2.06 and 366.69±44.15 respectively. Serum homocysteine level was found higher and folate level was found lower in patients with antiepileptic therapy which were statistically significant (p&lt;0.001). But serum B12 level difference was found statistically non-significant. Serum homocysteine level has a positive correlation (p-value 0.001, r value 0.71) and serum folate has a negative correlation (p-value 0.001, r value -0.65) with the duration of antiepileptic therapy.</p> <p><strong>Conclusion: </strong>A higher level of serum homocysteine and a lower level of folate was found in patients under antiepileptic therapy. But there was no significant change in the serum vitamin B12 level of these patients.</p> <p>J Rang Med Col. March 2023; Vol. 8, No. 2:44-48</p> Noor e Nazar Mst Munira Begum S N Sultana Shafiqus Saleheen Afsana Ferdous Majedul Islam Khadiza Parvin Copyright (c) 2023 Journal of Rangpur Medical College 2023-04-04 2023-04-04 8 1 44 48 10.3329/jrpmc.v8i1.65056 Prevalence of Hepatitis B Infection Among Healthy Blood Donors in Rangpur, Bangladesh <p><strong>Background: </strong>Transfusion transmitted infection (TTIs) is still an alarming issue associated with blood transfusion, as hepatitis B remains a critical public health concern in a country like Bangladesh. The predisposition of the prevalence of HBsAg infection among healthy blood donors even in a tertiary-level hospital could be a strategy for scheming and observing this problem.</p> <p><strong>Methods: </strong>A cross-sectional study was conducted among all samples of a total of 11,566 units of blood screening for hepatitis B surface antigen at Rangpur Medical College Hospital, Rangpur from January 2021 to December, 2021. The prevalence of HBV infection was measured to observe the trends. Data were collected by non-probability convenient sampling, maintaining inclusion and exclusion criteria. Face-to-face interviews, blood grouping tests, and hepatitis B surface antigen (HBsAg) screening were conducted.</p> <p><strong>Results: </strong>About 66% of the blood donors were between 18 and 30 years of age, and 89.6% of them were males. All the donors were replacement donors who came voluntarily. The overall seroprevalence rate of HBV among all healthy blood donors was 1.09%. About 98.4% of HBsAg-positive blood donors were males and only 1.6% were female. Hepatitis B infection was more prevalent in the 28–36 years age group and least prevalent among those older than 48 years of age.</p> <p><strong>Conclusion: </strong>The decreasing trend in the prevalence of HBV infection might be the result of improvement in donor recruitment and selection, built-up awareness, proper TTIs screening, HBV vaccination and possibly decreasing HBV infection prevalence in the general population.</p> <p>J Rang Med Col. March 2023; Vol. 8, No. 2:49-52</p> Jobaida Jannat Md Ashekur Rahman Mufeq Mahmud Md Zia Hayder Bosunia Abu Hena Md Shohel Rana Khousnoor Hanif Copyright (c) 2023 Journal of Rangpur Medical College 2023-04-04 2023-04-04 8 1 49 52 10.3329/jrpmc.v8i1.65059 Household Water, Sanitation, Hygiene Facilities and Practices in Selected Villages of Taraganj Upazilla, Rangpur <p><strong>Background: </strong>Water, sanitation and hygiene (WASH) facilities are considered a basic human necessity for survival and well-being, without these basic needs the health condition of millions of people, especially children and women are at risk. Bangladesh is vulnerable in this regard.</p> <p><strong>Objectives: </strong>The study aimed to assess household water, sanitation and hygiene facilities and practices in selected villages of Taraganj Upazilla, Rangpur.</p> <p><strong>Methods: </strong>This cross-sectional study was conducted among 341 rural households from six villages of Taraganj Upazilla, Rangpur district using a pretested semi-structured questionnaire and an observation checklist. Data were collected through face-to-face interview and observing the facilities.</p> <p><strong>Result: </strong>The respondents of this study were female predominant. Male: female ratio was 1:3 and their average age was 38.16(±14.03) years. Every household were using improved source of water for both drinking and other domestic purposes but only 4.7% households safely treated water for drinking and only in 17.9% households water source was found 50 feet or more from the latrine. About 70.7% respondents kept their drinking water storage container over shelf/table, covered it with lid (65.0%) and 90.4% containers were found clean during observation. Around 95.6% households used an improved toilet facility and in 45.7 % household latrine was situated in their own dwellings. Although on observation of latrines, water collection or storage facility, hand washing facility and soap or detergent availability near them were found 63.2%, 64.4% and 59.9% households respectively. Still 2.1% households had no toilet facility at all. Nearly 19.4% respondents shared their toilet facility with other households. About 90.3% households safely disposed their children’s stool. Majority of respondents told that they used soap during washing hands before meal (84.8%) and after defecation (98.2%).During observation of the site for hand washing, water supply and soap or detergent availability were found in 97.7% and 83.3% households respectively. Good practices for drinking water, sanitation and hygiene were found among 4.7%, 71.6% and 92.7% households respectively.</p> <p><strong>Conclusion: </strong>These findings are suggestive of need to come up with strategies of health education and promotion to ensure that rural households understand the importance of safe treatment of drinking water, safe disposal of child’s stool and safe distance of latrine from drinking water source in order to prevent spread of diseases. Effective policies should be developed by policymakers, safe distance of latrine from drinking water source and media and communication specialists should convey clear messages for everyone, particularly illiterate rural population.</p> <p>J Rang Med Col. March 2023; Vol. 8, No. 2:53-58</p> Munira Begum Md Shahriar Morshed Rehnuma Islam Most Masuma Islam Nisa Copyright (c) 2023 Journal of Rangpur Medical College 2023-04-04 2023-04-04 8 1 53 58 10.3329/jrpmc.v8i1.65060 Evaluation of Cardiovascular Sympathetic Nerve Function Status by Cold Pressor test in Healthy Adult Male Sedentary Individuals <p><strong>Background: </strong>Sedentary lifestyle is an issue of great concern because of its deleterious health implication. It is associated with limited physical activity. Regular physical activity with good physical fitness are widely accepted as factors that reduce all cause of mortality and improve number of health outcome.</p> <p><strong>Objective: </strong>To assess the cardiovascular sympathetic nerve function status by the cold pressor test in healthy adult male sedentary workers.</p> <p><strong>Methods: </strong>This cross-sectional analytical study was conducted from January 2019 to December 2019 in the Department of Physiology, Rangpur Medical College, Rangpur. After obtaining permission, a total 60 subjects who were met the inclusion criteria was enrolled in the study after briefing them objectives of the study. Among them 30 were healthy adult male heavy workers (Group-A) and 30 were healthy adult male sedentary workers (Group-B). The basal systolic and diastolic blood pressure was recorded in resting condition. The evaluation of sympathetic nerve functions in selected individuals was done by cold pressor test. The individuals were selected from different areas of Rangpur district. For statistical analysis unpaired t-test was performed by computer-based software SPSS-23.0 version for windows.</p> <p><strong>Results: </strong>The resting systolic and diastolic blood pressure are non-significant in selected individuals. Diastolic blood pressure response by cold pressor test was significantly lower in sedentary workers. (p&lt; 0.05).</p> <p><strong>Conclusion: </strong>The study thus concluded that decreased diastolic blood pressure response by cold pressor test in sedentary individuals indicate impairment of the sympathetic nerve function.</p> <p>J Rang Med Col. March 2023; Vol. 8, No. 2:59-64</p> Sharmin Sultana Chandra Rani Sarkar ATM Zoadur Rahim Zahid Rabindra Nath Barman Copyright (c) 2023 Journal of Rangpur Medical College 2023-04-04 2023-04-04 8 1 59 64 10.3329/jrpmc.v8i1.65061 Effect of Tobacco Consumption on Serum Alanine Aminotransferase and Alkaline Phosphatase Levels in Smoking <p><strong>Background: </strong>The use of tobacco has been significantly increased globally in recent decades. Easy availability and the low price gives rise to high consumption of tobacco smoking. Tobacco use is a leading preventable cause of premature mortality and morbidity.. Previous studies described the detrimental effects of tobacco smoking on liver function.</p> <p><strong>Objectives: </strong>To observe the effects of tobacco consumption on the levels of serum alanine aminotransferase and alkaline phosphatase levels in smokers<strong>.</strong></p> <p><strong>Methods: </strong>The cross-sectional analytical study was conducted from January 2017 to January 2018 in the department of physiology, Rangpur Medical College, Rangpur. A total number of 60 subjects were selected, among them 30 were apparently healthy non-tobacco chewer non-smoker subjects as control group ( group A) and 30 were apparently healthy smoker non-tobacco chewer subjects ( group B). The subjects were selected from different area of Rangpur city. The effects of cigarette smoking on liver function were studied by measuring the levels of serum alanine aminotransferase and alkaline phosphatase levels. For statistical analysis independent sample “t” test was performed by computer based software SPSS-17.0 version for windows<strong>.</strong></p> <p><strong>Results: </strong>Serum alanine aminotransferase and alkaline phosphatase levels were significantly higher (p&lt;0.001) in smoker non-tobacco chewer subjects as compared with the healthy control subjects.</p> <p><strong>Conclusion: </strong>The increased serum alanine aminotransferase and alkaline phosphatase levels in smoker non-tobacco chewer subjects were evidence of development of liver function impairment due to tobacco smoking and this might offer a new preventive approach to liver function impairment in population with tobacco smoking.</p> <p>J Rang Med Col. March 2023; Vol. 8, No. 1:65-68</p> Shapna Rani Roy Chandra Rani Sarkar ATM Zoadur Rahim Zahid Neaz Ahmed Copyright (c) 2023 Journal of Rangpur Medical College 2023-04-04 2023-04-04 8 1 65 68 10.3329/jrpmc.v8i1.65063 Fertility Outcome of Vasectomy Recanalization: A Review <p>Non Scalpel Vasectomy (NSV) is used extensively for male sterilization by the family planning industry in Bangladesh. But if NSV needs a reverse procedure (recanalization), variable rates are observed in different studies. We collected articles from Hinari, Pubmed and Banglajol with extensive searches. We compared these results between articles and recommended the best vasectomy reversal (NSV) procedure for male clients.</p> <p>J Rang Med Col. March 2023; Vol. 8, No. 1:69-71</p> Hriday Ranjan Roy Copyright (c) 2023 Journal of Rangpur Medical College 2023-04-04 2023-04-04 8 1 69 71 10.3329/jrpmc.v8i1.65065 Barriers of Researches in Medical Sector in Bangladesh-The Curtain in the Window <p>Abstract not available</p> <p>J Rang Med Col. September 2023; Vol. 8, No. 1:1-2</p> Shah Md Sarwer Jahan Copyright (c) 2023 Journal of Rangpur Medical College 2023-04-04 2023-04-04 8 1 1 2 10.3329/jrpmc.v8i1.64967