@article{Mounika_Pragathi_Gyanakumari_2010, title={Synthesis¸ Characterization and Biological Activity of a Schiff Base Derived from 3-Ethoxy Salicylaldehyde and 2-Amino Benzoic acid and its Transition Metal Complexes}, volume={2}, url={https://banglajol.info/index.php/JSR/article/view/4899}, DOI={10.3329/jsr.v2i3.4899}, abstractNote={<p class="MsoNormal" style="margin: 0cm 15.55pt 0pt 14.2pt; text-align: justify;"><span style="font-family: Times New Roman;"><span style="font-size: 9pt; color: #000000;">A new Schiff base, 3-ethoxy salicylidene amino benzoic acid (ETSAN), has been synthesized from 3-ethoxy salicylaldehyde and 2-amino benzoic acid. Metal complexes of the Schiff base were prepared from nitrate/chloride salts of Ni(II), Co(II) Cu(II) and Zn(II) in an alcoholic medium. The complexes were non-electrolytes in dimethyl sulfoxide <span style="mso-spacerun: yes;"> </span><span style="mso-spacerun: yes;"> </span>solvent (DMSO). The chemical structures of the Schiff-base ligand and its metal complexes were confirmed by various spectroscopic studies like IR, UV-VIS, <sup>1</sup>H NMR, <sup>13</sup>C NMR, ESI-mass spectra, elemental analysis, molar conductance, thermogravimetric studies and magnetic susceptibility measurements. On the basis of elemental and spectral studies, six-coordinated geometry was assigned to these complexes. In the light of these results, it is suggested that this ligand acts as neutral and tridentate and coordinates to each metal atom by azomethine nitrogen and oxygen atoms of hydroxyl group of the 3-ethoxy salicylaldehyde, besides the hydroxyl group of the carboxyl group of 2-amino benzoic acid. The mass spectral data confirm</span><span style="font-size: 9pt;" lang="EN-US">s the monomeric structure of the metal complexes while the TGA studies confirm the presence of water molecules in the complex. The free Schiff base and its complexes have been tested for their antibacterial as well as antifungal activity by using disc diffusion method and the results discussed.</span></span></p><p class="MsoNormal" style="margin: 0cm 15.55pt 0pt 14.2pt; text-align: justify;"> </p><p class="MsoNormal" style="margin: 0cm 15.55pt 0pt 14.2pt; text-align: justify;"><span style="font-family: Times New Roman;"><span style="font-size: 9pt;" lang="EN-US"><em></em></span></span></p><p class="MsoNormal" style="margin: 0cm 15.55pt 0pt 14.2pt; text-align: justify;"><span style="font-family: Times New Roman;"><span style="font-size: 9pt;" lang="EN-US"><em>Keywords:</em> Schiff base; 3-ethoxy salicylaldehyde; 2-amino benzoic acid; Metal complexes; Antibacterial activity; Antifungal activity.</span></span></p><p class="MsoBodyText" style="margin: 0cm 15.55pt 0pt 14.2pt; text-align: justify;"><span style="font-weight: normal; font-size: 6pt; mso-bidi-font-size: 9.0pt;" lang="EN-US"><span style="font-family: Times New Roman;"> </span></span></p><p class="MsoNormal" style="margin: 0cm 15.55pt 0pt 14.2pt; text-align: justify; mso-layout-grid-align: none;"><span style="font-size: 8pt; mso-ansi-language: EN-SG; mso-fareast-language: EN-SG;"><span style="font-family: Times New Roman;">© 2010 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.</span></span></p><p class="MsoNormal" style="margin: 0cm 15.55pt 0pt 14.2pt; text-align: justify; tab-stops: 14.2pt 6.0cm 177.2pt 184.3pt;"><span style="font-size: 2pt; mso-ansi-language: EN-SG; mso-fareast-language: EN-SG; mso-bidi-font-size: 8.0pt;"><span style="font-family: Times New Roman;"> </span></span></p><p class="MsoNormal" style="margin: 0cm 15.55pt 0pt 14.2pt; text-align: justify; tab-stops: 14.2pt 6.0cm 177.2pt 184.3pt;"><span style="font-family: Times New Roman;"><span style="font-size: 8pt; mso-ansi-language: EN-SG; mso-fareast-language: EN-SG;">DOI: 10.3329/jsr.v2i3.4899<span style="mso-spacerun: yes;">                 </span></span><span style="font-size: 8pt;" lang="EN-US">J. Sci. Res. 2 (3), 513-524 (2010)</span></span></p><p> </p>}, number={3}, journal={Journal of Scientific Research}, author={Mounika, K. and Pragathi, A. and Gyanakumari, C.}, year={2010}, month={Aug.}, pages={513} }