Antimicrobial Therapy in Preventing Wound Infection Following Appendicectomy in Uncomplicated Appendicitis: A Comparative Study Between Single Dose And Multiple Doses In Adults

Authors

  • Mohammad Ashraf Uddin Khan Junior Consultant, Department of Surgery, Dhaka Medical College Hospital, Dhaka
  • Md Alamgir Hossain Sikder Department of Surgery, Dhaka National Medical College, Dhaka
  • Arif Salam Khan Assistant Professor, Department of Surgery, Bangabandhu Sheikh Mujib Medical University, Dhaka
  • Md Ashiqur Rahman Assistant Professor, Department of Surgery, Khulna Medical College, Khulna, Bangladesh
  • Ahmed Sarni Al Hasan Junior Consultant, Department of Surgery, Sher-E-Bangla Medical College Hospital, Dhaka
  • Md Jahangir Hossain Medical Officer, Department of Surgery, Bangabandhu Sheikh Mujib Medical University, Dhaka
  • Mohammed Rafiqul lslam Medical Officer, Department of Surgery, Bangabandhu Sheikh Mujib Medical University, Dhaka

DOI:

https://doi.org/10.3329/jss.v19i1.43772

Keywords:

appendicectomy, single dose prophylactic antibiotics, Multiple doses post operative antibiotics, wound infection

Abstract

Objectives: To find out the efficacy of single dose antibiotic vs multiple dosesin preventing wound infection following appendicectomy for uncomplicated appendicitis.

Methods: A prospective comparative study was conducted in the Department of Surgery, Chittagong Medical college Hospital from January'2009 to June'2009. 100 patients with uncomplicated appendicitis who underwent appendicectomy during that period were included in this study. Among them 50 cases were included in study group ·(SG) who were given only single dose of combination drugs ( lnj. Cefuroxime + lnj. Metronidazole).ln rest of the 50 cases (CG), antibiotics were continued for 7 days postoperatively.

Result: Maximum incidence of acute appendicitis was in the 2nd and 3rd decade of life with male preponderance .Rate of wound infection in the study group and control group was 4% and 2% respectively which was not statistically significant .The duration of antibiotic therapy had no significant effect on the length of hospital stay between the two groups ; 2.48 days vs 2.9 days [mean + s.d. 69.6 # 16.8 hours ] in the study and control group respectively, though treatment cost was higher in control group in comparison to the study group .

Conclusion: Single dose of preoperative antibiotics is adequate for prevention of postoperative wound infection following appendicectomy for uncomplicated appendicitis.

Journal of Surgical Sciences (2015) Vol. 19 (1) : 17-20

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Published

2019-11-04

How to Cite

Khan, M. A. U., Sikder, M. A. H., Khan, A. S., Rahman, M. A., Hasan, A. S. A., Hossain, M. J., & lslam, M. R. (2019). Antimicrobial Therapy in Preventing Wound Infection Following Appendicectomy in Uncomplicated Appendicitis: A Comparative Study Between Single Dose And Multiple Doses In Adults. Journal of Surgical Sciences, 19(1), 17–20. https://doi.org/10.3329/jss.v19i1.43772

Issue

Vol. 19 No. 1 (2015)

Section

Original Articles

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