Nipple Skin Sparing Mastectomy and Immediate Reconstruction with implant using Acellular Dermal Matrix (ADM)in a Patient with TP53 mutation - First Experience in Bangladesh

Authors

  • SK Farid Ahmed Breast & Oncoplastic Breast Surgeon, Wycombe Hospital, Buckinghamshire Healthcare NHS Trust UK. Visiting Consultant and Advisor, Anwer Khan Modern Breast Care Unit and Research Centre, Dhaka, Bangladesh
  • Ali Nafisa Associate Professor, Department of Surgery, Anwer Khan Modern Medical College, Dhaka, Bangladesh
  • Samanta Meharin Priam Medical Officer, Anwer Khan Modern Medical College Hospital, Dhaka, Bangladesh
  • Hasnatul Ferdous Medical Officer, Anwer Khan Modern Medical College Hospital, Dhaka, Bangladesh
  • ASM Tanjilur Rahman Junior Consultant, Department of Surgery, Faridpur Medical College Hospital, Faridpur, Bangladesh
  • Md Salim Khan Project Director, Genomic Research Laboratory, Bangladesh Council of Scientific and Industrial Research (BCCI), Bangladesh
  • Mahedi Hassan Riad Intern Doctor, Department of Surgery, Anwer Khan Modern Medical College, Dhaka, Bangladesh

DOI:

https://doi.org/10.3329/jss.v24i2.52320

Keywords:

Acellular Dermal Matrix, Nipple Skin Sparing Mastectomy. Immediate Breast Reconstruction. TP53 mutation

Abstract

A 28-year-old lady presented with 3.5 cm lump in her right breast and normal axilla. Histopathologically the lump revealed as invasive duct cell cancer (IDC), Grade II with ER negative, PR positive and HER2 equivocal. On genetic testing, BRCA1 & BRCA2were found negative but p53 was positive with pathogenic variant. She received neoadjuvant chemotherapy while waiting for genetic testing. As she had TP53 mutation and considered high risk for developing contralateral breast cancer, bilateral mastectomy and immediate reconstruction with implant using acellular dermal matrix was performed on 9th of March,2020 at our Breast Unit during 2nd live surgery & workshop on oncoplastic breast surgery, organized by Breast Care Unit and Research Centre, Department of Surgery, Anwer Khan Modern Medical college. This is the first reported case of a breast cancer patient with TP53 mutation who has undergone nipple skin sparing mastectomy with immediate implant/ADM reconstruction and creates a milestone in the history of modern breast cancer management in Bangladesh.

Journal of Surgical Sciences (2020) Vol. 24 (2) : 77-82

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Published

2021-02-01

How to Cite

Ahmed, S. F., Nafisa, A., Priam, S. M., Ferdous, H., Rahman, A. T., Khan, M. S., & Riad, M. H. (2021). Nipple Skin Sparing Mastectomy and Immediate Reconstruction with implant using Acellular Dermal Matrix (ADM)in a Patient with TP53 mutation - First Experience in Bangladesh. Journal of Surgical Sciences, 24(2), 77–82. https://doi.org/10.3329/jss.v24i2.52320

Issue

Section

Case Reports