Impact of Momordica charantia (karela) on serum aspartate aminotransferase level in streptozotocin induced diabetic rats

Authors

  • S Mohal Professor, Department of Anatomy, ZH Sikder Women?s Medical College, Dhaka
  • DK Mondal Professor, Department of Anatomy, Gazi Medical College, Khulna
  • PK Chowdhury Assistant Professor, Respiratory Medicine, Khulna Medical College, Khulna
  • H Biswas Associate Professor, Department of Forensic Medicine, Diabetic Association Medical College, Faridpur
  • A Khanom Assistant Professor, Department of Gynae Onchology, National Cancer Research Institute & Hospital, Dhaka
  • KM Shamim Professor, Department of Anatomy, Bangabandhu Sheikh Mujib Medical University, Dhaka

DOI:

https://doi.org/10.3329/mediscope.v2i1.24735

Keywords:

Diabetes mellitus, Hyperglycemia, Serum aspartate aminotransferase, Momordica charantia (karela)

Abstract

The  present  experimental  study  was  conducted  to  investigate  whether  Momordica  charantia  (karela)  has  got  any  impact  on  serum  aspartate  aminotransferase  (AST)  level  in  the  streptozotocin induced diabetic rats. Sixty healthy young Long Evans rats of male sex weighing  150 to 280 gm aged between 10 to 12 weeks were used in this study. The rats were divided into  4 equal groups depending on their different sorts of dietary feedings and drug treatment. Serum  AST level was estimated in all rats up to day 51 from the day of streptozotocin/ vehicle injection.  The mean ± SD of final serum AST level as percentage of corresponding initial level (value on  51st day  to  the  value  on  7th day) was  95.1  ±  13.4  u/L  in  healthy  rats,  110.0  ±  7.6  u/L  in  the  untreated diabetic rats, 39.4 ± 10.1 u/L in the insulin-treated diabetic rats and 109.5 ± 23.8 u/L  in  the  karela-treated  diabetic  rats. The AST percentage  change  value  of  diabetic  rats  on  51st  day  corresponding  to  the  initial  on  7th day was  significantly  higher  than  that  healthy  rats  (p  <  0.01).  The  value  in  the  insulin-treated  diabetic  rats  was  significantly  lower  than  that  of  the  untreated diabetic rats (p < 0.001) and the karela-treated diabetic rats (p < 0.001). There was no  significant  difference  between  the  values  of  the  untreated  diabetic  rats  and  the  karela-treated  diabetic  rats  (p  >  0.05).  Karela showed  a  tendency  of  acting  against hyperglycemic  effects  of  streptozotocin  induced  diabetes  mellitus  and  also  acting  against  high  serum  aspartate  aminotransferase  (AST)  level  in  streptozotocin  induced  diabetes  mellitus.  However,  further  investigations  are  recommended  for  establishing  karela  as  a  safe  and  useful  effective  anti-hyperglycemic  agent  as  well  as  an  agent  acting  against  the  rise  in  serum  AST  level  in  streptozotocin induced diabetic rats.

Mediscope Vol. 2, No. 1: 2015, Pages 18-21

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Author Biography

S Mohal, Professor, Department of Anatomy, ZH Sikder Women?s Medical College, Dhaka



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Published

2015-08-27

How to Cite

Mohal, S., Mondal, D., Chowdhury, P., Biswas, H., Khanom, A., & Shamim, K. (2015). Impact of Momordica charantia (karela) on serum aspartate aminotransferase level in streptozotocin induced diabetic rats. Mediscope, 2(1), 18–21. https://doi.org/10.3329/mediscope.v2i1.24735

Issue

Vol. 2 No. 1 (2015)

Section

Original Articles

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