Possible hidden cause of human immunodeficiency virus type 1 latency and role of interferon

Authors

  • Nursarat Ahmed Assistant Professor, Department of Microbiology and Immunology, Gazi Medical College, Khulna
  • Kazuki Miura Professor, Department of Immunotherapeutics, Graduate School, Tokyo Medical and Dental University

DOI:

https://doi.org/10.3329/mediscope.v3i2.30162

Keywords:

HIV-1 latency, interferon, CD4 T cells

Abstract

Latent human immunodeficiency virus type 1 (HIV-1) infected cells under antiretroviral therapy are reported to be resting memory CD4+ T cells; however, the mechanisms of HIV-1 latency is unclear. We demonstrate that long-term culture of interleukin-2-dependent CD4+ T cells with a memory phenotype mimicked latently HIV-1-infected cells in the presence of interferon-?. These cells are mostly resting and contained HIV-1 proviruses that could be re-activated by stimulation. Our findings suggest a potential role of type-1 interferon in HIV-1 latency.

Mediscope Vol. 3, No. 2: July 2016, Pages 11-17

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Author Biography

Nursarat Ahmed, Assistant Professor, Department of Microbiology and Immunology, Gazi Medical College, Khulna



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Published

2016-10-31

How to Cite

Ahmed, N., & Miura, K. (2016). Possible hidden cause of human immunodeficiency virus type 1 latency and role of interferon. Mediscope, 3(2), 11–17. https://doi.org/10.3329/mediscope.v3i2.30162

Issue

Vol. 3 No. 2 (2016)

Section

Original Articles

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