Evaluation of lipid profile among children and adolescents with type 1 diabetes mellitus in Bangladesh

Authors

  • M Parveen Assistant Professor, Department of Biochemistry, Gazi Medical College, Khulna
  • MA Muttalib Professor, Department of Biochemistry, BIRDEM Academy, Dhaka
  • ST Huq Assistant Professor, Department of Biochemistry, Prime Medical College, Rangpur
  • N Nazneen Assistant Professor, Department of Community Medicine, Gazi Medical College, Khulna
  • MA Kabir Assistant Professor, Department of Biochemistry, Diabetic Association Medical College, Faridpur
  • MS Hossain Assistant Professor, Department of Biochemistry, Prime Medical College, Rangpur

DOI:

https://doi.org/10.3329/mediscope.v5i1.36721

Keywords:

lipid profile, children, adolescents, type 1 diabetes mellitus, Bangladesh

Abstract

The study, a cross-sectional survey, was carried out at the Department of Biochemistry in Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM) General Hospital from July 2015 to June 2016. A total of 576 clinically diagnosed children and adolescents with type 1 diabetes mellitus (T1DM) aged 10-18 years attending in ‘Changing Diabetes in Children’ clinic, BIRDEM-2, Dhaka were selected according to appropriate inclusion and exclusion criteria. The study subjects underwent detailed medical history and examination. Fasting blood samples were drawn from the participants for biochemical assays such as fasting blood sugar (FBS), glycated haemoglobin (HbA1c), total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides. Anthropometric data and blood pressures both systolic and diastolic were measured. Student unpaired t-test and Chi-square test were used to determine the association between different groups. Out of 576 T1DM patients, 45.0% (259) were male and 55.0% (317) were female. Of the 576 T1DM patients, 35.1% were without dyslipidemia (DLP) and 64.9% were with DLP. Study revealed that the patients with DLP were more likely to have higher values of HbA1c (10.1±2.2% vs 9.4±1.9%, p < 0.001) and FBS (13.0±4.4 mmol/L vs 10.2±2.9 mmol/L, p < 0.001). A substantial proportion of children and adolescents with T1DM had DLP. We found an association between poor glycemic control and abnormal lipid profiles in those patients.
Mediscope Vol. 5, No. 1: Jan 2018, Page 15-21

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Author Biography

M Parveen, Assistant Professor, Department of Biochemistry, Gazi Medical College, Khulna



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Published

2018-06-04

How to Cite

Parveen, M., Muttalib, M., Huq, S., Nazneen, N., Kabir, M., & Hossain, M. (2018). Evaluation of lipid profile among children and adolescents with type 1 diabetes mellitus in Bangladesh. Mediscope, 5(1), 15–21. https://doi.org/10.3329/mediscope.v5i1.36721

Issue

Vol. 5 No. 1 (2018)

Section

Original Articles

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