Serum Vitamin D Status and its Relationship with Metabolic Parameters in Patients with Type 2 Diabetes Mellitus

Authors

  • Md Tazul Islam Assistant Professor, Department of Biochemistry, Sheikh Hasina Medical College, Habiganj
  • Susmita Nargis Associate Professor, Department of Biochemistry, Ad-din Sakina Women’s Medical College, Jashore
  • Heera Lal Roy Associate Professor, Department of Biochemistry, Khulna City Medical College, Khulna
  • Ehsanul Islam Associate Professor, Department of Biochemistry, Ad-din Akij Medical College, Khulna
  • Mahmuda Sultana Associate Professor, Department of Anatomy, Parkview Medical College, Sylhet
  • Sarker Hafiz Mahmud Associate Professor, Department of Pharmacology & Therapeutics, Army Medical College, Cumilla cantonment, Cumilla

DOI:

https://doi.org/10.3329/mediscope.v9i2.61708

Keywords:

25-hydroxycholecalciferol [25(OH) D3], Type 2 diabetes mellitus.

Abstract

Vitamin D is a fat-soluble vitamin with hormonal functions, which helps in calcium and phosphate homeostasis and bone metabolism. Beyond the role in bone health, vitamin D influences non-skeletal health problems and chronic diseases like obesity, hypertension, cardiovascular diseases, glucose intolerance and type 2 diabetes mellitus (T2DM). Low vitamin D impairs insulin synthesis and secretion resulting in glucose intolerance in T2DM. This study was carried out between July 2015 to June 2016 to assess vitamin D status in T2DM patients. In this study, vitamin D {25-hydroxycholecalciferol [25(OH)D3]} was assessed in 65 type 2 diabetes mellitus patients and 70 healthy subjects of matching age and sex. Serum 25-hydroxycholecalciferol, fasting blood glucose (FBG), total cholesterol and serum creatinine were estimated. Data were analyzed with the help of the statistical package “R” (version 2.7). Serum 25-hydroxycholecalciferol in cases (Group A) was 55.73±9.02 ng/ml and in controls (Group B) was 53.77±10.86 ng/ml; there was no statistically significant difference between the two groups. Serum FBG was significantly different between the two groups, whereas serum total cholesterol and serum creatinine were not significantly different between the two groups. In type 2 diabetes patients, no significant correlation was found between serum 25-hydroxycholecalciferol with Body mass index (BMI), fasting blood glucose and total cholesterol. In healthy controls, there was no significant correlation of serum 25-hydroxycholecalciferol with BMI, fasting blood glucose and total cholesterol. Vitamin D level was sufficient in both type 2 diabetes patients and healthy individuals. Vitamin D was not associated with T2DM.

Mediscope 2022;9(2): 75-80

Downloads

Abstract
61
PDF
70

Downloads

Published

2022-10-10

How to Cite

Islam, M. T. ., Nargis, S. ., Roy, H. L., Islam, E. ., Sultana, M., & Mahmud, S. H. . (2022). Serum Vitamin D Status and its Relationship with Metabolic Parameters in Patients with Type 2 Diabetes Mellitus. Mediscope, 9(2), 75–80. https://doi.org/10.3329/mediscope.v9i2.61708

Issue

Vol. 9 No. 2 (2022)

Section

Original Articles

License

Copyright (c) 2022 MT Islam, S Nargis, HL Roy, E Islam, M Sultana, SH Mahmud

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish in the Mediscope agree to the following terms that:

  1. Authors retain copyright and grant Mediscope the right of first publication of the work.

  2. Creative Commons Licence
    Articles in Mediscope are licensed under a Creative Commons Attribution 4.0 International License CC BY-4.0. This license permits use, distribution and reproduction in any medium, provided the original work is properly cited.
  1. Authors are able to enter into separate, additional contractual arrangements for the distribution of the journal’s published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  2. Authors are permitted to post their work online (e.g., in institutional repositories or on their website) as it can lead to productive exchanges, as well as greater citation of published work.