Expression of p53 Protein in Different Grades of Gastric Carcinoma

Authors

  • Rezwana Karim Associate Professor, Department of Pathology, US-Bangla Medical College & Hospital, Narayanganj, Bangladesh.
  • Sadia Afroz OSD, DGHS, Ministry of Health and Family Welfare, Dhaka, Bangladesh.
  • Syeda Noorjahan Karim Associate Professor, Department of Pathology, Gazi Medical College, Khulna, Bangladesh.
  • Faiza Nusrat Assistant Professor, Department of Pathology, East West Medical College, Dhaka, Bangladesh.
  • Nafisa Sermin Clinical Pathologist, Department of Clinical Pathology, Dhaka Medical College, Dhaka, Bangladesh.
  • Sampurna Sen Associate professor & Head, Department of Pathology, Ad-din Sakina Women’s Medical College, Jashore, Bangladesh.
  • Ummey Salma Shabnam Assistant Professor (Histopathology), Department of Histopathology, National Institute of Cancer Research and Hospital, Dhaka, Bangladesh.
  • Tasmia Islam Specialist-pathology, Square Hospitals Ltd, Dhaka, Bangladesh.

DOI:

https://doi.org/10.3329/mediscope.v11i2.76378

Keywords:

Gastric adenocarcinoma, p53 protein, Immunohistochemical expression

Abstract

Background: Mutation in the TP53 suppressor gene and accumulation of p53 protein are the common genetic events in gastric carcinomas. This mutation has been associated with abnormalities in cell cycle regulation, DNA repair and synthesis, apoptosis, and suggested to be implicated in the prognosis of gastric carcinoma.

Objectives: To assess the immunohistochemical expression of p53 protein in gastric carcinoma and to study the association of p53 protein expression with different histopathological grade of gastric carcinoma.

Methods: In this cross-sectional observational study, 60 paraffin blocks of gastric adenocarcinoma were re-evaluated and histopathological grading were assessed. The p53 expression in the tumour cell nucleus of the submitted blocks were assessed by standard immunoperoxidase method. Appropriate positive control was run for each batch of slides.

Results: Out of 60 cases, most of them 35 cases were poorly differentiated carcinoma, of which 28(80%) showed high expression and 7(20%) showed low expression of p53 protein. Twenty cases were moderately differentiated carcinoma, of which 12(60%) showed high expression and 8(40%) low expression. Only 5 were well differentiated carcinoma and all of which showed low expression of p53 protein. So, it was seen that with advancing grade of tumor, frequency of high expression of p53 protein was high and yielded statistically significant result (p value = 0.001).

Conclusion: There was a significant association between immunohistochemical expression of p53 protein and histopathological grading of gastric adenocarcinoma. These results indicate that immunohistochemical expression of p53 protein is an important prognostic factor of gastric adenocarcinoma, allowing the selection of a group of patients with an extensive therapeutic indication.

Mediscope 2024;11(2): 48-51

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Published

2024-11-06

How to Cite

Karim, R., Afroz, S., Karim, S. N., Nusrat, F., Sermin, N., Sen, S., Shabnam, U. S., & Islam, T. (2024). Expression of p53 Protein in Different Grades of Gastric Carcinoma. Mediscope, 11(2), 48–51. https://doi.org/10.3329/mediscope.v11i2.76378

Issue

Vol. 11 No. 2 (2024)

Section

Original Articles

License

Copyright (c) 2024 Rezwana Karim, Sadia Afroz, Syeda Noorjahan Karim, Faiza Nusrat, Nafisa Sermin, Sampurna Sen, Ummey Salma Shabnam, Tasmia Islam

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