Correlation of E-cadherin Immunoexpression with Histopathological Grading of Oral Squamous Cell Carcinoma

Authors

  • F M Khaliduzzaman Assistant Professor, Department of Pathology, Gazi Medical College Khulna, Bangladesh.
  • A Q M Abdul Hye Professor & Former Head, Department of Pathology, Sylhet MAG Osmani Medical College, Bangladesh.
  • Shamim Akhter Mimi Professor & Head, Department of Pathology, Sylhet MAG Osmani Medical College, Bangladesh.
  • Nibedita Das Pew Associate Professor, Department of Pathology, Sylhet MAG Osmani Medical College, Bangladesh.
  • Abu Saeed Bin Hasem Lecturer, Department of Pathology, Sylhet MAG Osmani Medical College, Bangladesh.
  • Abdullah Al Faroque Associate Professor & Head, Department of Pathology, Gazi Medical College, Khulna, Bangladesh.
  • Syeda Noorjahan Karim Associate Professor, Department of Pathology, Gazi Medical College, Khulna, Bangladesh.
  • Tasnim Rahman Associate Professor, Department of Pathology, Gazi Medical College, Khulna, Bangladesh.

DOI:

https://doi.org/10.3329/mediscope.v12i1.79891

Keywords:

OSCC, E-cadherin, Immunoexpression

Abstract

Background: Cancers arising from the oral cavity are mostly squamous cell carcinoma. E-cadherin is encoded by the CDH1 gene that helps in maintaining cell polarity and normal tissue architecture. Loss of E-cadherin expression is associated with tumor differentiation, invasion, metastasis and poor prognosis.

Objectives: To assess the E-cadherin expression in different grades of oral squamous cell carcinoma (OSCC) and to determine the association of E-cadherin expression with histological grades, age & gender of OSCC patients.

Methods: This cross-sectional observational study was conducted at the Department of Pathology, Sylhet MAG Osmani Medical College, from July 2021 to June 2022. A total of 53 (small biopsy and resected) OSCC cases were processed; paraffin blocks were made and stained with routine H&E stain. The sections were examined microscopically and the tumors were graded histologically. Immunohistochemistry was performed by using a commercially available anti-E-cadherin antibody. Immunoreactivity was calculated by multiplying the expression score and the intensity score.

Results: Out of 53 cases of OSCC, most of the cases (35/53) were found in the buccal mucosa (66.0%) followed by in the tongue (18.9%). 50.9% of patients belonged to Grade-I, 43.4% were Grade-II and 5.7% were Grade-III OSCC. Regarding E-cadherin, 56.6% of cases showed positive expression, 39.6% cases showed reduced expression and 3.8% cases showed negative expression. Negative expression was found only in 2 (66.7%) Grade III cases of OSCC. A significant correlation was seen between E-cadherin expression with histological grading but not with age and gender.

Conclusion: E-cadherin might be a valuable tool for predicting OSCC patient outcomes and it can be further used for therapeutic targets.

Mediscope 2025;12(1): 23-28

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Published

2025-03-17

How to Cite

Khaliduzzaman, F. M., Hye, A. Q. M. A., Mimi, S. A., Pew, N. D., Hasem, A. S. B., Faroque, A. A., … Rahman, T. (2025). Correlation of E-cadherin Immunoexpression with Histopathological Grading of Oral Squamous Cell Carcinoma. Mediscope, 12(1), 23–28. https://doi.org/10.3329/mediscope.v12i1.79891

Issue

Vol. 12 No. 1 (2025)

Section

Original Articles

License

Copyright (c) 2025 F.M. Khaliduzzaman, A Q M Abdul Hye, Shamim Akhter Mimi, Nibedita Das Pew, Abu Saeed Bin Hasem, Abdullah Al-Faroque, Syeda Noorjahan Karim, Tasnim Rahman

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