Immature reticulocyte fraction as a predictor of bone marrow recovery in children with acute lymphoblastic leukaemia on remission induction phase

Authors

  • S Yesmin Department of Pathology, Dhaka Community Medical College, Dhaka
  • T Sultana Department of Clinical Pathology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka
  • CK Roy Department of Clinical Pathology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka
  • MQ Rahman Department of Clinical Pathology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka
  • ANN Ahmed Department of Clinical Pathology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka

DOI:

https://doi.org/10.3329/bmrcb.v37i2.8435

Keywords:

Immature reticulocyte fraction, predictor, bone marrow recovery, children, acute lymphoblastic leukaemia, remission induction phase

Abstract

Immature reticulocyte fraction a new routine parameter in the hematology analyzer can give the idea of the earliest morphologic change of bone marrow recovery before other test become positive after chemotherapy. A prospective observational study was carried out in the Department of Clinical Pathology in collaboration with Paediatric Haematology and Oncology, Bangabandhu Sheikh Mujib Medical University during a period of one year starting from October 2009 to September 2010 to evaluate the bone marrow recovery in children with acute lymphoblastic leukaemia by automated reticulocyte analysis. Total fifty patients were enrolled in this study on remission induction phase. All patients were between 8 months to 15 years age range with a mean age of 5.5 ± 3.2. At the end of the study out of 50 cases, 52% patients showed early immature reticulocyte fraction recovery and concluded that the immature reticulocyte fraction parameter showed earlier haematopoietic recovery than the current practice of absolute neutrophil count recovery.

DOI: http://dx.doi.org/10.3329/bmrcb.v37i2.8435

BMRCB 2011; 37(2): 57-60

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How to Cite

Yesmin, S., Sultana, T., Roy, C., Rahman, M., & Ahmed, A. (2011). Immature reticulocyte fraction as a predictor of bone marrow recovery in children with acute lymphoblastic leukaemia on remission induction phase. Bangladesh Medical Research Council Bulletin, 37(2), 57–60. https://doi.org/10.3329/bmrcb.v37i2.8435

Issue

Vol. 37 No. 2 (2011)

Section

Research Papers

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