Liver Enzymes In Diabetic And Non Diabetic Subjects With Clinically Diagnosed Hepatitis

Authors

  • Bidhan Chandra Sarkar Bangladesh Institute of Research & Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Dhaka
  • Hasi Rani Saha Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi
  • Palash Kumar Sarker National Institute of Biotechnology, Savar, Dhaka
  • Niranjan Kumar Sana Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi
  • M Abu Sayeed Department of Community Medicine, Ibrahim Medical College, Dhaka
  • Subhagata Choudhury Bangladesh Institute of Research & Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Dhaka

DOI:

https://doi.org/10.3329/imcj.v5i2.10098

Keywords:

Liver function tests (LFTs), bilirubin, ALT, AST, ALP, hepatitis

Abstract

The occurrence of liver disease and raised liver enzymes is common in diabetic patients and the increasing level of enzymes indicates the severity of hepatic injury. Very few studies have addressed this issue in Bangladesh though Bangladeshi population is very much susceptible to diabetes.

This study investigated a total of 1400 diabetic patients and 100 non diabetic individuals to compare the level of liver enzymes between diabetic and non-diabetic subjects. The comparisons were made among subjects who were referred to the department of Gastro-hepato-pancreatic diseases (GHPD) of BIRDEM with the clinical diagnosis of chronic hepatitis and other gastro-intestinal disorders. The investigations included alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and bilirubin levels. The subjects were categorized with and without hepatitis based on these investigations.

The biochemical markers (ALT, AST, ALP, bilirubin) did not differ significantly between nondiabetic male and female subjects. Neither the differences were significant between diabetic males and females though the diabetic patients had higher level of markers. In contrast, when compared between diabetic and non-diabetic subjects there were striking differences in either sex. Compared with the non-diabetic the diabetic subjects had significantly higher level of ALT (48.3 vs. 277.0), AST (42.0 vs. 213.0) and ALP (148 vs. 302) in males (p<0.005 for all). Similarly, these values were found significantly higher in diabetic females than their non-diabetic counterparts (p<0.01). For bilirubin, it was also found significant in males (p<0.001).

The study revealed that the liver enzymes were found elevated in both diabetic and non-diabetic subjects who were referred with clinically diagnosed hepatitis. The enzymes were found markedly elevated among the diabetic than non diabetic patients, which indicate hepatic injury was more marked among the diabetic patients. Further study may confirm these findings. It is suggested that other socio-demographic and biophysical risk factors are important to be investigated in order to prevent increased hepatic damage among the diabetic subjects.

DOI: http://dx.doi.org/10.3329/imcj.v5i2.10098

IMCJ 2011; 5(2): 46-50

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How to Cite

Sarkar, B. C., Saha, H. R., Sarker, P. K., Sana, N. K., Sayeed, M. A., & Choudhury, S. (2012). Liver Enzymes In Diabetic And Non Diabetic Subjects With Clinically Diagnosed Hepatitis. Ibrahim Medical College Journal, 5(2), 46–50. https://doi.org/10.3329/imcj.v5i2.10098

Issue

Vol. 5 No. 2 (2011)

Section

Original Articles