Serological response of commercial dairy cattle to inactivated foot-and-mouth disease vaccine (type-O & A) in Nigeria

Authors

  • David Dazhia Lazarus Foot-and-Mouth Disease Laboratory, National Veterinary Research Institute
  • Yiltawe Simwal Wungak Foot-and-Mouth Disease Laboratory, National Veterinary Research Institute
  • Mohammed Ignatius Adah Department of Medicine, College of Veterinary Medicine, University of Agriculture, Makurdi
  • John Okpapi Ibu Department of Microbiology and Pathology, College of Veterinary Medicine, University of Agriculture, Makurdi
  • Jerry Ngutor Abenga Department of Microbiology and Pathology, College of Veterinary Medicine, University of Agriculture, Makurdi
  • Pius Stephen Ekong Central Diagnostic Laboratory, National Veterinary Research Institute
  • Hussaini Gulak Ularamu Foot-and-Mouth Disease Laboratory, National Veterinary Research Institute

DOI:

https://doi.org/10.3329/ajmbr.v1i2.25606

Keywords:

commercial, dairy, foot-and-mouth-disease, inactivated, response, serological, vaccine

Abstract

An observational study was conducted in a peri-urban dairy establishment in Jos South, Plateau State Nigeria to determine immune response of dairy cattle to commercial inactivated foot-and-mouth disease vaccine serotypes (O and A). Thirty seven Friesian cattle aged ?2years old with their crosses (15 selected pre-vaccination and 22 selected 21 days post-vaccination) were investigated for immune response to vaccination with an inactivated trivalent FMD vaccine containing serotypes O, A and SAT 2). Sera collected on day 0 pre-vaccination and 21 days post-vaccination was tested for structural protein antibodies to FMD serotypes O and A using the Solid Phase Competitive ELISA assay. The mean OD value for serum end point titre of FMD serotype O pre-vaccination was 11.64% with 6.67% (95%CI: 0.33 28.73) of the selected cattle being seropositive, at 21 days post-vaccination the mean OD value in selected cattle was 52.83% with 68.18% (95%CI: 46.95 84.89) of the selected cattle seropositive. For the FMD serotype A, 26.67% (95%CI: 9.10 52.53) of the selected cattle were seropositive pre-vaccination with a mean OD value of 29.21% and by 21 days post-vaccination, 72.73% (95%CI: 51.67 88.13) of the selected cattle were seropositive with a mean OD value of 61.70%. Serological response to vaccination improved in most selected cattle by 21 days post-vaccination. This study result has indicated that commercial inactivated FMD vaccines used for the prophylactic control of FMD in commercial dairy farm in Nigeria provoked immune response after a single shot.

Asian J. Med. Biol. Res. June 2015, 1(2): 163-168


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Author Biography

David Dazhia Lazarus, Foot-and-Mouth Disease Laboratory, National Veterinary Research Institute



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Published

2015-11-23

How to Cite

Lazarus, D. D., Wungak, Y. S., Adah, M. I., Ibu, J. O., Abenga, J. N., Ekong, P. S., & Ularamu, H. G. (2015). Serological response of commercial dairy cattle to inactivated foot-and-mouth disease vaccine (type-O & A) in Nigeria. Asian Journal of Medical and Biological Research, 1(2), 163–168. https://doi.org/10.3329/ajmbr.v1i2.25606

Issue

Vol. 1 No. 2 (2015)

Section

Articles