Serological response of commercial dairy cattle to inactivated foot-and-mouth disease vaccine (type-O & A) in Nigeria

Authors

  • David Dazhia Lazarus Foot-and-Mouth Disease Laboratory, National Veterinary Research Institute
  • Yiltawe Simwal Wungak Foot-and-Mouth Disease Laboratory, National Veterinary Research Institute
  • Mohammed Ignatius Adah Department of Medicine, College of Veterinary Medicine, University of Agriculture, Makurdi
  • John Okpapi Ibu Department of Microbiology and Pathology, College of Veterinary Medicine, University of Agriculture, Makurdi
  • Jerry Ngutor Abenga Department of Microbiology and Pathology, College of Veterinary Medicine, University of Agriculture, Makurdi
  • Pius Stephen Ekong Central Diagnostic Laboratory, National Veterinary Research Institute
  • Hussaini Gulak Ularamu Foot-and-Mouth Disease Laboratory, National Veterinary Research Institute

DOI:

https://doi.org/10.3329/ajmbr.v1i2.25606

Keywords:

commercial, dairy, foot-and-mouth-disease, inactivated, response, serological, vaccine

Abstract

An observational study was conducted in a peri-urban dairy establishment in Jos South, Plateau State Nigeria to determine immune response of dairy cattle to commercial inactivated foot-and-mouth disease vaccine serotypes (O and A). Thirty seven Friesian cattle aged ?2years old with their crosses (15 selected pre-vaccination and 22 selected 21 days post-vaccination) were investigated for immune response to vaccination with an inactivated trivalent FMD vaccine containing serotypes O, A and SAT 2). Sera collected on day 0 pre-vaccination and 21 days post-vaccination was tested for structural protein antibodies to FMD serotypes O and A using the Solid Phase Competitive ELISA assay. The mean OD value for serum end point titre of FMD serotype O pre-vaccination was 11.64% with 6.67% (95%CI: 0.33 28.73) of the selected cattle being seropositive, at 21 days post-vaccination the mean OD value in selected cattle was 52.83% with 68.18% (95%CI: 46.95 84.89) of the selected cattle seropositive. For the FMD serotype A, 26.67% (95%CI: 9.10 52.53) of the selected cattle were seropositive pre-vaccination with a mean OD value of 29.21% and by 21 days post-vaccination, 72.73% (95%CI: 51.67 88.13) of the selected cattle were seropositive with a mean OD value of 61.70%. Serological response to vaccination improved in most selected cattle by 21 days post-vaccination. This study result has indicated that commercial inactivated FMD vaccines used for the prophylactic control of FMD in commercial dairy farm in Nigeria provoked immune response after a single shot.

Asian J. Med. Biol. Res. June 2015, 1(2): 163-168


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Author Biography

David Dazhia Lazarus, Foot-and-Mouth Disease Laboratory, National Veterinary Research Institute



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Published

2015-11-23

How to Cite

Lazarus, D. D., Wungak, Y. S., Adah, M. I., Ibu, J. O., Abenga, J. N., Ekong, P. S., & Ularamu, H. G. (2015). Serological response of commercial dairy cattle to inactivated foot-and-mouth disease vaccine (type-O & A) in Nigeria. Asian Journal of Medical and Biological Research, 1(2), 163–168. https://doi.org/10.3329/ajmbr.v1i2.25606

Issue

Vol. 1 No. 2 (2015)

Section

Research Articles

License

Copyright (c) 2015 David Dazhia Lazarus, Yiltawe Simwal Wungak, Mohammed Ignatius Adah, John Okpapi Ibu, Jerry Ngutor Abenga, Pius Stephen Ekong, Hussaini Gulak Ularamu

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.