Dextran sulfate sodium-induced colitis mice up-regulated extracellular matrix tenascin-C

Authors

  • Md Shafiqul Islam Department of Pharmacology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh-2202
  • Masatoshi Hori Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo
  • Hiroshi Ozaki Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo

DOI:

https://doi.org/10.3329/ajmbr.v2i4.31000

Keywords:

tenascin-C, DSS, colitis, macrophage

Abstract

Tenascin-C, an extracellular matrix glycoprotein, expresses high level during embryogenesis and almost absent during the normal postnatal life. However, it is re-appeared in a diverse condition such as tissue injury and in the stroma of various carcinomas. In this study, we investigated the appearance of tenascin-C in dextran sulfate sodium (DSS)-induced colitis in mice. DSS induced colitis mice demonstrated severe mucosal damage, with distortion and loss of crypts, depletion of goblet cells and infiltration of macrophages particularly F4/80 positive macrophages, granulocytes and lymphocytes in the colon tissues. These DSS inflamed colon expressed a high and dense level of tenascin-C in the severe damaged areas, whereas, moderate staining was observed in the moderate inflamed areas. DSS-induced colitis mice significantly increased macrophages infiltration in the colon tissues. These results suggested that tenascin-C extracellular matrix re-appeared in the colon tissues during inflammation.

Asian J. Med. Biol. Res. December 2016, 2(4): 582-586

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Author Biography

Md Shafiqul Islam, Department of Pharmacology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh-2202



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Published

2017-01-23

How to Cite

Islam, M. S., Hori, M., & Ozaki, H. (2017). Dextran sulfate sodium-induced colitis mice up-regulated extracellular matrix tenascin-C. Asian Journal of Medical and Biological Research, 2(4), 582–586. https://doi.org/10.3329/ajmbr.v2i4.31000

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