Role of macrophages in atherosclerosis

Authors

  • Afrin Sultana Chowdhury Department of Biotechnology and Genetic Engineering, Noakhali Science and Technology University, Noakhali, Bangladesh
  • Saheda Tamanna Department of Biotechnology and Genetic Engineering, Noakhali Science and Technology University, Noakhali, Bangladesh
  • Kumkum Kar Department of Biotechnology and Genetic Engineering, Noakhali Science and Technology University, Noakhali, Bangladesh

DOI:

https://doi.org/10.3329/ajmbr.v6i3.49784

Keywords:

atherosclerosis; macrophages; chemokines

Abstract

Atherosclerosis is a chronic inflammatory state, which arise from the imbalance in lipid metabolism. Over the last decade, studies have showing the association of macrophages with this maladaptive immune response. Macrophages differentiated from monocytes and populate at the growing atherosclerotic lesions. At the lesion site by accumulating lipid they actively participate in the formation of atherosclerotic plaque. These plaques are very susceptible to rupture which can lead to myocardial infarction or stroke. In future more studies are needed to classify different macrophage populations according to their phenotypic and functional characteristics to identify their roles in the pathogenesis of atherosclerosis. This review highlights several aspects of macrophages activation, diversity, recruitment, and foam cell formation in atherosclerosis.

Asian J. Med. Biol. Res. September 2020, 6(3): 366-374

Downloads

Download data is not yet available.
Abstract
306
PDF
207

Downloads

Published

2020-10-17

How to Cite

Chowdhury, A. S., Tamanna, S., & Kar, K. (2020). Role of macrophages in atherosclerosis. Asian Journal of Medical and Biological Research, 6(3), 366–374. https://doi.org/10.3329/ajmbr.v6i3.49784

Issue

Vol. 6 No. 3 (2020)

Section

Review Articles

License

Authors who publish with this journal agree to the following terms / The author(s) affirm(s) that:

  1. The manuscript submitted is based on authors own research and is original work.
  2. Authors certify that we all participated in the research work and preparation of the manuscript in a substantive way.
  3. Authors also declare that they have read and approved the manuscript.
  4. Authors further declare that the manuscript has not been published in part or full and is not being submitted or considered for publication in part or full elsewhere.
  5. Any material included in the manuscript does not violate copyright or other rights of anyone. 
  6. Authors  also affirm that the article contains no vilifying or unlawful statements and does not contain material or instructions that might cause harm or injury to the Editor-in-Chief/Editors of the Journal and the public.
  7. Authors assure Asian J. Med. Biol. Res. and the Editor-in-Chief/Editors of the Journals, and hold them harmless from any loss, expense or damage occurred by a claim or suit by a third party for copyright violation, or any suit arising out of any violation of the foregoing warranties as a result of publication of my/our article. 
  8. In consideration of authors manuscript submitted, authors hereby grant Asian J. Med. Biol. Res. unlimited, worldwide, permanent royalty-free, right to publish, use, dispense, license, transmit, display, exhibit, record, store, translate, digitize, broadcast, reproduce and archive, in any format or medium, whether now known or developed hereafter.

All materials related to manuscripts, accepted or rejected, including photographs, original figures etc., will be kept by Asian J. Med. Biol. Res. for one year following the editor’s decision. These materials will then be destroyed.