Antioxidant and acetylcholinesterase activities of three species of the family Lamiaceae

Abstract

Antioxidant and acetylcholinesterase inhibitory activity of the three species namely, Endostemon obtusifolius (E. Mey. ex benth.) N. E. Br, Plectranthus zuluensis (T. Cooke) and Tetradenia riparia (Hochst.) Codd. were evaluated. Maximum antioxidant activity was exhibited by E. obtusifolius (IC₅₀ 130 ?g/ml) followed by T. riparia (IC₅₀ 142 ?g/ml) and P. zuluensis (IC₅₀ 169 ?g/ml). Acetylcholinesterase inhibition (AChEI) was highest in P. zuluensis (IC₅₀ 290 ?g/ml) followed by E. obtusifolius (IC₅₀ 470 ?g/ml) and T. riparia (IC₅₀ 750?g/ml). The results suggest that these three species possess natural antioxidants and acetylcholinesterase inhibitors, which may be beneficial for the treatment of Alzheimers disease, that require high concentration of these compounds.

DOI: http://dx.doi.org/10.3329/bjb.v43i3.21606

Bangladesh J. Bot. 43(3): 331-335, 2014 (December)