Pharmacological, Phytochemical and Computational Studies on Prenylated Flavonoids and Pterocarpans From Erythrina Fusca Lour.

Authors

  • Muneera Binta Yahya Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh
  • Mohammad Firoz Khan Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia.
  • Hasnat E Emtiaz Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh
  • Mahfuza Afroz Soma Department of Pharmacy, State University of Bangladesh, Dhaka, 1205, Bangladesh.
  • Muhammad Abdullah Al Mansur Institute of National Analytical Research and Service (INARS), Bangladesh Council of Scientific and Industrial Research (BCSIR), Dr. Qudrat-I-Khuda Road, Dhanmondi, Dhaka 1205, Bangladesh.
  • Mohammad A Rashid Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh
  • Mohammad Sharifur Rahman Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh

DOI:

https://doi.org/10.3329/bjb.v53i2.74050

Keywords:

Erythrina fusca, Flavonoid, Pterocarpan, Molecular docking, Cyclooxygenase, Drug-likeliness

Abstract

In the present study, the dry powdered bark of Erythrina fusca was extracted with methanol. It was subjected to peripheral analgesic study using the acetic acid-induced writhing test in mice model and it demonstrated significant analgesic activity. The methanol extract was partitioned into n-hexane, chloroform and water-soluble fractions. Primarily, the chloroform fraction of the methanol extract was subjected to various chromatographic techniques and four major metabolites, Lupinifolin (1), Lupinifolin-4’-methyl ether (2), Sandwicensin (3) and Licoagrocarpin (4) were purified. Molecular docking studies of 1-4 against cyclooxygenase-2 (COX-2) enzyme suggest that they may interact with COX-2 at different levels. The pharmacokinetic and biological parameters of 1-4 were also checked through in silico tool to understand their drug-likeliness.

Bangladesh J. Bot. 53(2): 305-311, 2024 (June)

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Published

2024-06-27

How to Cite

Yahya, M. B. ., Khan, M. F. ., Emtiaz, H. E., Soma, M. A. ., Al Mansur, M. A. ., Rashid , M. A. ., & Rahman, M. S. . (2024). Pharmacological, Phytochemical and Computational Studies on Prenylated Flavonoids and Pterocarpans From Erythrina Fusca Lour. Bangladesh Journal of Botany, 53(2), 305–311. https://doi.org/10.3329/bjb.v53i2.74050

Issue

Vol. 53 No. 2 (2024)

Section

Articles

License

© Bangladesh Botanical Society

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