Evaluation of antidiabetic activities of linseed (linum usitatissimum l.) Sprout extracts in adult Streptozotocin-induced (a-stz) long-evan rats

Authors

  • Mohammad Zakerin Abedin Department of Microbiology, Khwaja Yunus Ali University, Sirajganj, Bangladesh.
  • Laila Jarin Microbiology Laboratory, Department of Botany, Jahangirnagar University, Savar, Dhaka, Bangladesh
  • Mala Khan Bangladesh Reference Institute for Chemical Measurements (BRiCM), Dhaka, Bangladesh.
  • Rasheda Yasmin Shilpi Microbiology Laboratory, Department of Botany, Jahangirnagar University, Savar, Dhaka, Bangladesh

DOI:

https://doi.org/10.3329/bjb.v53i3.76264

Keywords:

Streptozotocin, Long-Evan rats, Antidiabetic Activity, Linum usitatissimum L.

Abstract

The study investigates the anti-diabetic properties of linsseed (Linum usitatissimum L.) sprout extracts in adult streptozotocin (STZ)-induced Long-Evan rats, addressing the limitations of existing treatment strategies in Bangladesh. The diabetic rats were administered orally with 400 mg/kg body weight of methanolic extracts of linseed sprout with a lab diet and glibenclamide as a positive control. Blood sugar levels were measured before, after, and after STZ injection in Long- Evan rats. The lipid profiles and liver function tests were performed. Administration of extracts of linseed sprouts and a standard anti-diabetic drug reduced the glucose level from 9.1 mmol/l to 6.0 mmol/l and 10.5 mmol/l to 6.6 mmol/l , respectively. The study also showed a healthy level of liver function tests and lipid profiles. The in vivo analysis of the potential antidiabetic activity of linseed sprouts in the STZ-induced diabetic mouse model might be used to treat and manage diabetes.

Bangladesh J. Bot. 53(3): 503-510, 2024 (September)

Downloads

Download data is not yet available.
Abstract
48
PDF
29

Downloads

Published

2024-09-29

How to Cite

Abedin, M. Z., Jarin, L., Khan, M., & Shilpi, R. Y. (2024). Evaluation of antidiabetic activities of linseed (linum usitatissimum l.) Sprout extracts in adult Streptozotocin-induced (a-stz) long-evan rats. Bangladesh Journal of Botany, 53(3), 503–510. https://doi.org/10.3329/bjb.v53i3.76264

Issue

Vol. 53 No. 3 (2024)

Section

Articles

License

© Bangladesh Botanical Society

Authors are required to transfer the copyright of their articles to the journal. The Declaration form is available here http://www.bdbotsociety.org/journal/journal_pdf/declaration_form.pdf