Pulmonary Manifestations of Primary Immunodeficiencies in Children - A Review

Authors

  • ARM Luthful Kabir Professor, Department of Pediatrics, Ad-din Women,s Medical College (AWMC), Dhaka
  • Sudipta Roy Assistant Professor, Department of Pediatrics, AWMC, Dhaka

DOI:

https://doi.org/10.3329/bjch.v42i2.37764

Keywords:

Primary immunodeficiency, Pulmonary manifestations, Children

Abstract

Primary immunodeficiency diseases (PIDs) are inherited defects of the innate or adaptive arms of the immune system that differs from secondary immunodeficiencies. Respiratory disorders are significant causes of morbidity and the leading causes of death (30% -65%) in both children and adults with PIDs. The spectrum of respiratory manifestations is extremely wide due to PIDs. PIDs are broadly classified according to the components of the immune system that is primarily disrupted. Predominant antibody deficiency disorders are the most frequent and comprise approximately 70-75% of all PIDs. The most common clinical manifestations are infections involving the respiratory tract e.g. rhinosinusitis, otitis media, bronchitis, bronchiectasis and recurrent pneumonia (30% -65%). Recurrent respiratory infections are often the first warning sign. Timely diagnosis and appropriate therapy can improve or at least decelerate the progression of these complications. Infectious and non-infectious respiratory complications determinate the patient’s prognosis. These complications are associated with significant morbidity and mortality in PID patients. Appropriate awareness of these manifestations is essential, especially for the pulmonologist to reduce morbidity and mortality in PID patients.

Bangladesh J Child Health 2018; VOL 42 (2) :86-93

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Published

2018-07-31

How to Cite

Kabir, A. L., & Roy, S. (2018). Pulmonary Manifestations of Primary Immunodeficiencies in Children - A Review. Bangladesh Journal of Child Health, 42(2), 86–93. https://doi.org/10.3329/bjch.v42i2.37764

Issue

Section

Review Article