CANDLE Syndrome: Case Report of a Rare Type of Auto- Inflammatory Disease

Authors

  • Md Asif Ali Resident, Department of Paediatrics, BSMMU, Dhaka
  • Mohammad Imnul Islam Professor of Paediatrics, Department of Paediatrics, BSMMU, Dhaka
  • Shahana Akhtar Rahman Professor of Paediatrics, Department of Paediatrics, BSMMU, Dhaka

DOI:

https://doi.org/10.3329/bjch.v44i3.52711

Keywords:

CANDLE syndrome, fever, lipodystrophy

Abstract

CANDLE syndrome (chronic atypical neutophilic dermatosis with lipodystrophy and elevated temperature) is an autoinflammatory disease/syndrome characterized by recurrent fever, skin lesions, and multisystem inflammatory manifestations. Most of the patients have shown mutation in PSMB8 gene. Here, we report a 9-year-old girl with recurrent fever, atypical facies, widespread skin lesions, generalized lymphadenopathy, hepato-splenomegaly, lipodystrophy, and failure to thrive. Considering the clinical features and laboratory investigations including skin biopsy findings, diagnosis was consistent with CANDLE syndrome. Therefore, it is recommended to consider CANDLE syndrome in a young child who presents with recurrent fever, characteristics rashes, organomegaly and failure to thrive.

Bangladesh J Child Health 2020; VOL 44 (3) :174-177

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Published

2021-03-29

How to Cite

Ali, M. A., Islam, M. I., & Rahman, S. A. (2021). CANDLE Syndrome: Case Report of a Rare Type of Auto- Inflammatory Disease. Bangladesh Journal of Child Health, 44(3), 174–177. https://doi.org/10.3329/bjch.v44i3.52711

Issue

Vol. 44 No. 3 (2020)

Section

Case Reports