The Efficacy of Subcutaneous Versus Oral Methotrexate in Patients with Juvenile Idiopathic Arthritis

Abstract

Objective: To investigate the efficacy of subcutaneous versus oral methotrexate in
patients with Juvenile Idiopathic Arthritis (JIA) according to ACR 30 improvement criteria.
Design: Prospective control trial (Parallel design) study.
Setting: This study was carried out in the department of Paediatrics, Bangabandhu
Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh, during the period
from September 2006 to April 2008.
Patients: A total of 40 patients participated in the study. They were divided in 2 equal
groups (Group A and Group B) alternatively matching with age, sex, and subtypes of
the disease. Methotrexate was given orally in group A patients and subcutaneously in
group B patients.
Results: Amomg the core set variables active arthritis had the highest percentage of
improvement in both the groups and laboratory criteria (ESR) showed lowest
improvement. According to ACR-30 criteria, improvement rate was higher in the
subcutaneous group than oral group (85% versus 65%). Side effects of MTX were
also less in subcutaneous group than oral group.
Conclusion: From this study it may be concluded that the efficacy of subcutaneous
MTX is more than oral MTX in JIA patients.

Key words: Subcutaneous; oral; methotrexate; juvenile idiopathic arthritis.

DOI: 10.3329/bjch.v33i1.5671

Bangladesh Journal of Child Health 2009; Vol.33(1): 22-26