Frequency and Risk Factors of Seizures in Children During Induction Remission Chemotherapy for Acute Lymphoblastic Leukemia (ALL)

Authors

  • Shahinoor Akter Soma Junior Consultant (Paediatrics), UHC, Nawabganj, Dhaka, Bangladesh
  • Chowdhury Yakub Jamal Professor, Department of Paediatric Hematology and Oncology, BSMMU, Dhaka, Bangladesh
  • Indira Chowdhury Ex Resident, Department of Paediatric Hematology and Oncology, BSMMU, Dhaka, Bangladesh
  • Farah Diba Junior Consultant (Paediatrics),UHC keraniganj, Dhaka, Bangladesh
  • Mousumi Saha Assistant registrar, Department of Paediatrics, Faridpur Medical College Hospital, Faridpur, Bangladesh

DOI:

https://doi.org/10.3329/bjch.v45i2.60085

Keywords:

Seizure, Acute lymphoblastic leukemia (ALL), risk factors, induction remission chemotherapy

Abstract

Background: Seizure is one of the most common CNS complications among patients receiving chemotherapy for acute lymphoblastic leukemia (ALL). Seizures are seen in 8-13% of patients with ALL. Most seizure occurs during the induction and consolidation phases of treatment. However, not much is known about the risk factors of these seizure.

Materials & Method: This prospective observational study was conducted in the department of Pediatric Hematology and Oncology, BSMMU. One hundred and five newly diagnosed admitted children with ALL aged >1 year to <18 years, from May 2017 to March 2018 for induction remission chemotherapy and who fulfilled the criteria of case definition were enrolled into this study.

Results: This study showed that seizure frequency was14.3% in children with ALL getting induction remission chemotherapy. Female patients developed seizures more than males which was statistically significant by univariate analysis (p = 0.029) but was not found to be a risk factor by multivariate analysis (p = 0.059). All the seizures developed in B-lineage ALL but there was no statistically significant association between lineage of ALL with development of seizures.

Conclusions: In this study slightly higher frequency of seizure in ALL patients on induction remission chemotherapy was found than previous studies (14.3% vs. 13%). Females developed seizures more than males.

BANGLADESH J CHILD HEALTH 2021; VOL 45 (2) : 94-98

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Published

2022-06-09

How to Cite

Soma, S. A. ., Jamal, C. Y. ., Chowdhury, I. ., Diba, F. ., & Saha, M. . (2022). Frequency and Risk Factors of Seizures in Children During Induction Remission Chemotherapy for Acute Lymphoblastic Leukemia (ALL). Bangladesh Journal of Child Health, 45(2), 94–98. https://doi.org/10.3329/bjch.v45i2.60085

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Original Articles