Role of Interleukin-6 and Interleukin-8 Cytokines as Early Diagnostic Markers of Sepsis

Authors

  • Mohammad Moniruzzaman Assistant Professor, Department of Immunology, Bangladesh Institute of Health Science, Dhaka, Bangladesh
  • Ashesh Kumar Chowdhury Associate Professor Department of Immunology, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine & Metabolic Disorders, Dhaka, Bangladesh
  • ASM Areef Ahsan Associate Professor, Department of Critical Care Medicine, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders, Dhaka, Bangladesh
  • Md Zakiur Rahman Professor Department of Microbiology, Monno Medical College, Manikgonj, Bangladesh
  • Saimun Nahar Rumana Lecturer, Department of Physiology, Ibrahim Medical College, Dhaka, Bangladesh
  • Md Abdullah Yusuf Assistant Professor, Department of Microbiology, National Institute of Neurosciences & Hospital, Dhaka, Bangladesh
  • Gobindo Chandra Saha Associate Professor, Department of Physiology, Cox’s Bazar medical College, Cox’s Bazar, Bangladesh

DOI:

https://doi.org/10.3329/bjid.v6i2.46102

Keywords:

Interleukin-6; Interleukin-8; Procalcitonin; C-reactive protein; Microbiological culture; Systemic inflammatory response syndrome (SIRS); Sepsis; Intensive care unit (ICU)

Abstract

Background: Rapid diagnosis is essential for effective therapy among the patients with sepsis.

Objectives: The purpose of the present study was to determine the relationship of serum levels of IL-6, IL-8 in patients with various stages of sepsis.

Methodology: This case control study was conducted in the Department of Immunology at Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Dhaka from January 2015 to December 2015 for a period of one (01) year. All patients had been selected from the ICU of BIRDEM General Hospital with known clinicopathological parameters of sepsis. Serum levels of IL-6 and IL-8 were assessed using Enzyme Linked Immunosorbent Assay (ELISA) method.

Results: In this study, a total of 80 subjects was enrolled of which 60 patients were with at least 2 SIRS criteria and 20 healthy age matched controls without SIRS. Significant difference was found in IL-6 and IL-8 values in the patients with bacteriological culture positive and negative group (p<0.05). AUC for IL-6 was 0.710 (95% CI 0.580-0.840), sensitivity 54.16%, specificity 59.09%, PPV 74.28% and NPV 52% with cutoff value >177pg/ml.

Conclusion: Elevated levels of serum IL-6 and IL-8 is found in the patients with sepsis

Bangladesh Journal of Infectious Diseases 2019;6(2):34-38

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Published

2020-03-20

How to Cite

Moniruzzaman, M., Chowdhury, A. K., Ahsan, A. A., Rahman, M. Z., Rumana, S. N., Yusuf, M. A., & Saha, G. C. (2020). Role of Interleukin-6 and Interleukin-8 Cytokines as Early Diagnostic Markers of Sepsis. Bangladesh Journal of Infectious Diseases, 6(2), 34–38. https://doi.org/10.3329/bjid.v6i2.46102

Issue

Vol. 6 No. 2 (2019)

Section

Original Articles

License

Copyright (c) 2019 Mohammad Moniruzzaman, Ashesh Kumar Chowdhury, ASM Areef Ahsan, Md Zakiur Rahman, Saimun Nahar Rumana, Md Abdullah Yusuf, Gobindo Chandra Saha

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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Copyright on any research article in the Bangladesh Journal of Infectious Diseases is retained by the author(s).

The authors grant the Bangladesh Infection Research Association a license to publish the article and identify itself as the original publisher.

Articles in the Bangladesh Journal of Infectious Diseases are Open Access articles published under the Creative Commons CC BY-NC License (https://creativecommons.org/licenses/by-nc/4.0/)

This license permits use, distribution and reproduction in any medium, provided the original work is properly cited, and it is not used for commercial purposes.