Determination of Interleukin 31 (IL-31) serum levels according to severity of allergic rhinitis

Authors

  • Noor Suryani Mohd Ashari School of Medical Sciences, Universiti Sains Malaysia, Kelantan
  • Siti Noor Syuhada Mohd Amin School of Medical Sciences, Universiti Sains Malaysia, Kelantan
  • Wan Zuraida Wan Abdul Hamid School of Medical Sciences, Universiti Sains Malaysia, Kelantan
  • Azriani Abdul Rahman School of Medical Sciences, Universiti Sains Malaysia, Kelantan
  • Irfan Muhammad School of Medical Sciences, Universiti Sains Malaysia, Kelantan

DOI:

https://doi.org/10.3329/bjms.v14i4.20393

Keywords:

IL-31, serum levels, ELISA, allergic rhinitis

Abstract

Objective: This study was conducted to compare IL-31 serum levels in allergic rhinitis (AR) patients and normal controls as well as according to severity of AR. Materials and Methods: The subjects, normal controls and AR patients, were defined by history taking. Blood were collected from subjects and patients with AR. Serum was centrifuged and analyzed for IL-31 using enzyme linked immunosorbent assay (ELISA) kits. 70 samples of normal controls and 70 samples of AR were collected respectively. Results and Discussion: The result showed that IL-31 serum level was higher in allergic rhinitis patients, mean (SD) 4107.70 (16961.51) as compared with normal controls 2195.55 (9016.57), however it was not statistically significance with p-value, 0.406 by using independent-T test. The result also showed no significant difference of IL-31 levels according to severity of AR with p-value, 0.245 by using Mann-Whitney test. Conclusions: IL-31 serum level was higher in AR patients; however it was not statistically significant. There was also no significant difference of IL-31 levels between the severity of AR. Further study which obtain the larger sample sizes should be done to get better findings.

Bangladesh Journal of Medical Science Vol.14(4) 2015 p.359-362

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Author Biographies

Noor Suryani Mohd Ashari, School of Medical Sciences, Universiti Sains Malaysia, Kelantan

Department of Immunology

Siti Noor Syuhada Mohd Amin, School of Medical Sciences, Universiti Sains Malaysia, Kelantan

Department of Immunology

Wan Zuraida Wan Abdul Hamid, School of Medical Sciences, Universiti Sains Malaysia, Kelantan

Department of Immunology

Azriani Abdul Rahman, School of Medical Sciences, Universiti Sains Malaysia, Kelantan

Department of Community Medicine

Irfan Muhammad, School of Medical Sciences, Universiti Sains Malaysia, Kelantan

Department of Otorhinolaryngology Head and Neck Surgery

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Published

2015-12-11

How to Cite

Mohd Ashari, N. S., Mohd Amin, S. N. S., Wan Abdul Hamid, W. Z., Abdul Rahman, A., & Muhammad, I. (2015). Determination of Interleukin 31 (IL-31) serum levels according to severity of allergic rhinitis. Bangladesh Journal of Medical Science, 14(4), 359–362. https://doi.org/10.3329/bjms.v14i4.20393

Issue

Vol. 14 No. 4 (2015)

Section

Original Articles

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