Prenatal PUFA undernutrition and risk of adult psychiatric disorders

Authors

  • Ariful Islam Department of Pharmacy, Rajshahi University, Rajshahi-6205

DOI:

https://doi.org/10.3329/bjms.v15i3.21775

Keywords:

PUFAs, FABP, prenatal undernutrition, psychiatric disorder

Abstract

The developing fetus requires significant amounts of poly unsaturated fatty acids (PUFAs/ FAs) to maintain its normal cellular growth and integrity. Suboptimal intrauterine conditions, including poor PUFAs nutrition, during critical periods of growth may lead to lifelong changes in the bodys organs and tissues, thus providing a physiological basis for adultonset disease. However, the Developmental Origins of Health and Disease (DOHaD) model provide a structure to assess the effect of early nutrition and growth on long-term health. Epidemiological statistics shows that when pregnant mothers experienced malnutrition or famine (e.g. the Dutch Hunger Winter of 1944-1945 and the Chinese famine of 1959-1961), the risk of developing metabolic and psychiatric disease in their children increased. The theory of DOHaD is well referenced in the understanding of adult metabolic diseases, but less so in the field of psychiatric disorders. As PUFAs play critical roles in brain development, considerable effort has been taken in elucidating their function in the pathogenesis of neuropsychiatric disorders.

Bangladesh Journal of Medical Science Vol.15(3) 2016 p.313-319

Downloads

Download data is not yet available.
Abstract
1
PDF
1

Downloads

Published

2016-11-03

How to Cite

Islam, A. (2016). Prenatal PUFA undernutrition and risk of adult psychiatric disorders. Bangladesh Journal of Medical Science, 15(3), 313–319. https://doi.org/10.3329/bjms.v15i3.21775

Issue

Vol. 15 No. 3 (2016)

Section

Review Article

License

Authors who publish in the Bangladesh Journal of Medical Science agree to the following terms that:

  1. Authors retain copyright and grant Bangladesh Journal of Medical Science the right of first publication of the work.

  2. Creative Commons Licence
    Articles in Bangladesh Journal of Medical Science are licensed under a Creative Commons Attribution 4.0 International License CC BY-4.0.This license permits use, distribution and reproduction in any medium, provided the original work is properly cited.
  3. Authors are able to enter into separate, additional contractual arrangements for the distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  4. Authors are permitted to post their work online (e.g., in institutional repositories or on their website) as it can lead to productive exchanges, as well as greater citation of published work.