Comparison of the effects of L-type calcium channel antagonist Amlodipine with L/N-type calcium channel antagonist Cilnidipine on blood pressure, heart rate, proteinuria and lipid profile in hypertensive patients

Authors

  • Kiran Kumar Singal Associate Professor, Department of Obs. & Gynae, M. M. Institute of Medical Sciences & Research, Mullana, Ambala (133203)
  • Neerja Singal Resident, Department of Medicine, M. M. Institute of Medical Sciences & Research, Mullana, Ambala (133203)
  • Abhinav Gupta Resident, Department of Medicine, M. M. Institute of Medical Sciences & Research, Mullana, Ambala (133203)
  • Akash Garg Resident, Department of Medicine, M. M. Institute of Medical Sciences & Research, Mullana, Ambala (133203)
  • Ravi Kumar Resident, Department of Medicine, M. M. Institute of Medical Sciences & Research, Mullana, Ambala (133203)

DOI:

https://doi.org/10.3329/bjms.v15i3.22536

Keywords:

calcium channel antagonist, cilnidipine, amlodipine, hypertension, proteinuria, pulse rate (PR), systolic BP (SBP), diastolic BP (DBP)

Abstract

Background: Cilnidipine is a novel and unique 1,4-dydropyridine derivative calcium antagonist that exerts potent inhibitory actions not only on L-type but also on N-type voltage dependent calcium channels. Blockade of the neural N-type calcium channel inhibits the secretion of norepinephrine from peripheral neural terminals and depresses sympathetic nervous system activity.

Objective and methods: The purpose of this study was to assess the effect of Cilnidipine and Amlodipine on blood pressure (BP) levels. We did BP monitoring before and after once-daily use of Cilnidipine and Amlodipine in 100 hypertensive patients.

Results: Both drugs significantly reduced systolic BP (SBP) and diastolic BP (DBP). However, the reductions in pulse rate (PR) were significantly greater in the Cilnidipine group than the Amlodipine group. N-type calcium channel blockade by Cilnidipine may not cause reflex tachycardia, and may be useful for hypertensive treatment.

Conclusion: There was significant reduction in proteinuria with Clindipine as compared to Amlodipine. However, there were no significant change in total cholesterol level in diabetes and non-diabetics in both the group.

Bangladesh Journal of Medical Science Vol.15(3) 2016 p.460-465

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Author Biographies

Neerja Singal, Resident, Department of Medicine, M. M. Institute of Medical Sciences & Research, Mullana, Ambala (133203)

 

Ravi Kumar, Resident, Department of Medicine, M. M. Institute of Medical Sciences & Research, Mullana, Ambala (133203)


 

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Published

2016-11-03

How to Cite

Singal, K. K., Singal, N., Gupta, A., Garg, A., & Kumar, R. (2016). Comparison of the effects of L-type calcium channel antagonist Amlodipine with L/N-type calcium channel antagonist Cilnidipine on blood pressure, heart rate, proteinuria and lipid profile in hypertensive patients. Bangladesh Journal of Medical Science, 15(3), 460–465. https://doi.org/10.3329/bjms.v15i3.22536

Issue

Vol. 15 No. 3 (2016)

Section

Original Articles

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