Comparison of the effects of L-type calcium channel antagonist Amlodipine with L/N-type calcium channel antagonist Cilnidipine on blood pressure, heart rate, proteinuria and lipid profile in hypertensive patients

Authors

  • Kiran Kumar Singal Associate Professor, Department of Obs. & Gynae, M. M. Institute of Medical Sciences & Research, Mullana, Ambala (133203)
  • Neerja Singal Resident, Department of Medicine, M. M. Institute of Medical Sciences & Research, Mullana, Ambala (133203)
  • Abhinav Gupta Resident, Department of Medicine, M. M. Institute of Medical Sciences & Research, Mullana, Ambala (133203)
  • Akash Garg Resident, Department of Medicine, M. M. Institute of Medical Sciences & Research, Mullana, Ambala (133203)
  • Ravi Kumar Resident, Department of Medicine, M. M. Institute of Medical Sciences & Research, Mullana, Ambala (133203)

DOI:

https://doi.org/10.3329/bjms.v15i3.22536

Keywords:

calcium channel antagonist, cilnidipine, amlodipine, hypertension, proteinuria, pulse rate (PR), systolic BP (SBP), diastolic BP (DBP)

Abstract

Background: Cilnidipine is a novel and unique 1,4-dydropyridine derivative calcium antagonist that exerts potent inhibitory actions not only on L-type but also on N-type voltage dependent calcium channels. Blockade of the neural N-type calcium channel inhibits the secretion of norepinephrine from peripheral neural terminals and depresses sympathetic nervous system activity.

Objective and methods: The purpose of this study was to assess the effect of Cilnidipine and Amlodipine on blood pressure (BP) levels. We did BP monitoring before and after once-daily use of Cilnidipine and Amlodipine in 100 hypertensive patients.

Results: Both drugs significantly reduced systolic BP (SBP) and diastolic BP (DBP). However, the reductions in pulse rate (PR) were significantly greater in the Cilnidipine group than the Amlodipine group. N-type calcium channel blockade by Cilnidipine may not cause reflex tachycardia, and may be useful for hypertensive treatment.

Conclusion: There was significant reduction in proteinuria with Clindipine as compared to Amlodipine. However, there were no significant change in total cholesterol level in diabetes and non-diabetics in both the group.

Bangladesh Journal of Medical Science Vol.15(3) 2016 p.460-465

Downloads

Download data is not yet available.
Abstract
7
PDF
11

Author Biographies

Neerja Singal, Resident, Department of Medicine, M. M. Institute of Medical Sciences & Research, Mullana, Ambala (133203)

 

Ravi Kumar, Resident, Department of Medicine, M. M. Institute of Medical Sciences & Research, Mullana, Ambala (133203)


 

Downloads

Published

2016-11-03

How to Cite

Singal, K. K., Singal, N., Gupta, A., Garg, A., & Kumar, R. (2016). Comparison of the effects of L-type calcium channel antagonist Amlodipine with L/N-type calcium channel antagonist Cilnidipine on blood pressure, heart rate, proteinuria and lipid profile in hypertensive patients. Bangladesh Journal of Medical Science, 15(3), 460–465. https://doi.org/10.3329/bjms.v15i3.22536

Issue

Vol. 15 No. 3 (2016)

Section

Original Articles

License

Authors who publish in the Bangladesh Journal of Medical Science agree to the following terms that:

  1. Authors retain copyright and grant Bangladesh Journal of Medical Science the right of first publication of the work.

  2. Creative Commons Licence
    Articles in Bangladesh Journal of Medical Science are licensed under a Creative Commons Attribution 4.0 International License CC BY-4.0.This license permits use, distribution and reproduction in any medium, provided the original work is properly cited.
  3. Authors are able to enter into separate, additional contractual arrangements for the distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  4. Authors are permitted to post their work online (e.g., in institutional repositories or on their website) as it can lead to productive exchanges, as well as greater citation of published work.