Honey potentially mitigates morphine analgesic tolerance and physical dependence in rats

Authors

  • Siti Norhajah Hashim PhD student Faculty of Medicine, Universiti Sultan Zainal Abidin (UniSZA), Opioid Research Interest Group, Faculty of Medicine, Universiti Sultan Zainal Abidin (UniSZA), 20400, Kuala Terengganu, Terengganu
  • Nasir Mohamad Medical lecturer,Faculty of Medicine, Universiti Sultan Zainal Abidin (UniSZA), Opioid Research Interest Group, Faculty of Medicine, Universiti Sultan Zainal Abidin (UniSZA), 20400, Kuala Terengganu, Terengganu
  • Zulkifli Mustapha Lecturer,Comparative Neurosciences, Universiti Sains Malaysia, Malaysia, Kelantan
  • Nor Hidayah Abu Bakar Medical lecturer,Faculty of Medicine, Universiti Sultan Zainal Abidin (UniSZA), Opioid Research Interest Group, Faculty of Medicine, Universiti Sultan Zainal Abidin (UniSZA), 20400, Kuala Terengganu, Terengganu
  • Rohayah Husain Medical lecturer,Faculty of Medicine, Universiti Sultan Zainal Abidin (UniSZA), Opioid Research Interest Group, Faculty of Medicine, Universiti Sultan Zainal Abidin (UniSZA), 20400, Kuala Terengganu, Terengganu
  • Khairi Che Mat Medical lecturer,Faculty of Medicine, Universiti Sultan Zainal Abidin (UniSZA), Opioid Research Interest Group, Faculty of Medicine, Universiti Sultan Zainal Abidin (UniSZA), 20400, Kuala Terengganu, Terengganu
  • Nur Husna Zakaria MSc student Faculty of Medicine, Universiti Sultan Zainal Abidin (UniSZA), Opioid Research Interest Group, Faculty of Medicine, Universiti Sultan Zainal Abidin (UniSZA), 20400, Kuala Terengganu, Terengganu
  • Liyana Hazwani Mohd Adnan PhD student Faculty of Medicine, Universiti Sultan Zainal Abidin (UniSZA), Opioid Research Interest Group, Faculty of Medicine, Universiti Sultan Zainal Abidin (UniSZA), 20400, Kuala Terengganu, Terengganu
  • Halim Shariff PhD student Faculty of Medicine, Universiti Sultan Zainal Abidin (UniSZA), Opioid Research Interest Group, Faculty of Medicine, Universiti Sultan Zainal Abidin (UniSZA), 20400, Kuala Terengganu, Terengganu
  • Mohd UlulIlmie Research officer Faculty of Medicine, Universiti Sultan Zainal Abidin (UniSZA), 20400, Kuala Terengganu, Terengganu

DOI:

https://doi.org/10.3329/bjms.v17i1.35294

Keywords:

Honey, mitigate, morphine tolerance dependence

Abstract

Introduction:Honey has been used traditionally in medicine as well as food supplements. Honeybees are said to be able to cure many diseases. However, its influences on opioid tolerance and dependence have not yet been clarified.

Materials and Methods:Adult male Sprague- Dawley rats were rendered tolerant to the analgesic effect of morphine by injection of morphine (10 mg/kg, i.p.) twice daily for 14 days. To develop morphine dependence rats given escalating doses of chronic morphine. To determine the effect of stingless bee honey on the development of morphine tolerance and dependence. The hotplate and naloxone precipitation tests were used to assess the degree of tolerance and dependence, respectively.

The results: Our results showed that chronic morphine-injected rats displayed tolerance to the analgesic effect of morphine as well as morphine dependence. Methadone+morphine (MetM), methadone+morphine+ honey (MetMH) and morphine+Honey (MH) significantlylower the development of morphine tolerance with p-value p<0.05. In addition, concomitant treatment of morphine with MH and MetMH attenuated almost all of the naloxone-induced withdrawal signs which include abdominal contraction, diarrhea, pertussis, teeth chattering, and jumping.

Conclusion: The data indicate that honey has a potential to reduce tolerant and dependence property.

Bangladesh Journal of Medical Science Vol.17(1) 2018 p.138-143

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Published

2018-01-11

How to Cite

Hashim, S. N., Mohamad, N., Mustapha, Z., Bakar, N. H. A., Husain, R., Mat, K. C., Zakaria, N. H., Mohd Adnan, L. H., Shariff, H., & UlulIlmie, M. (2018). Honey potentially mitigates morphine analgesic tolerance and physical dependence in rats. Bangladesh Journal of Medical Science, 17(1), 138–143. https://doi.org/10.3329/bjms.v17i1.35294

Issue

Vol. 17 No. 1 (2018)

Section

Original Articles

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