Lupus Cofactor Effect of Mixing Study: Example of a Case Report and Revisit on Theoretical Aspects

Authors

  • Wan Suriana Wan Ab Rahman 1 School of Dental Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan
  • Zefarina Zulkafli 3 Department of Hematology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan
  • Mohd Nazri Hassan 2 Department of Hematology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan
  • Wan Zaidah Abdullah 2 Department of Hematology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan

DOI:

https://doi.org/10.3329/bjms.v18i2.40721

Keywords:

lupus anticoagulant; mixing study; inhibitor

Abstract

Background: Lupus anticoagulants (LA) are in vitro inhibitors paradoxically associated with thrombosis and performing coagulation test on a mixture of test plasma and pooled normal plasma to evidence this property is a mainstay in LA detection.

Case report: We report a 20-year-old man who presented with one week history of fever, associated with productive cough, jaundice, and lethargy. He was a known case of systemic lupus erythemathosus for 10 years. Isolated activated partial thromboplastin time (APTT) were prolonged. Interestingly, the APTT mixing study was not corrected and showed more prolonged results than baseline APTT. LA study showed presence of a strong LA, which is related to the underlying autoimmune disease.

Discussion: This case focuses on the ‘rebound phenomenon’ in APTT mixing test, from a strong LA that gives a cofactor inhibitory effect to the entire test system after adding the normal plasma.

Bangladesh Journal of Medical Science Vol.18(2) 2019 p.430-433

Downloads

Download data is not yet available.
Abstract
1
PDF
1

Downloads

Published

2019-03-25

How to Cite

Rahman, W. S. W. A., Zulkafli, Z., Hassan, M. N., & Abdullah, W. Z. (2019). Lupus Cofactor Effect of Mixing Study: Example of a Case Report and Revisit on Theoretical Aspects. Bangladesh Journal of Medical Science, 18(2), 430–433. https://doi.org/10.3329/bjms.v18i2.40721

Issue

Vol. 18 No. 2 (2019)

Section

Case Reports

License

Authors who publish in the Bangladesh Journal of Medical Science agree to the following terms that:

  1. Authors retain copyright and grant Bangladesh Journal of Medical Science the right of first publication of the work.

  2. Creative Commons Licence
    Articles in Bangladesh Journal of Medical Science are licensed under a Creative Commons Attribution 4.0 International License CC BY-4.0.This license permits use, distribution and reproduction in any medium, provided the original work is properly cited.
  3. Authors are able to enter into separate, additional contractual arrangements for the distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  4. Authors are permitted to post their work online (e.g., in institutional repositories or on their website) as it can lead to productive exchanges, as well as greater citation of published work.