Correlation of VEGF expression with prognostic factors of breast carcinoma

Authors

  • Jhuma Nandi Junior Resident, Department Of Pathology, NRS Medical College, Kolkata
  • Moumita Maiti Assistant Professor, Department Of Pathology, NRS Medical College, Kolkata, India
  • Neepamanjari Barman Assistant Professor, Department Of Pathology, NRS Medical College, Kolkata
  • Moumita Paul Assistant Professor, Department Of Pathology, NRS Medical College, Kolkata
  • Sreepurna Medda Demonstrator , Department Of Pathology, NRS Medical College, Kolkata
  • Sushil Ranjan Ghosal Professor and Head, Department Of Surgery, NRS Medical College, Kolkata
  • Ranu Sarkar Professor and Head, Department Of Pathology, NRS Medical College, Kolkata

DOI:

https://doi.org/10.3329/bjms.v18i3.41619

Keywords:

Correlation of VEGF, prognostic factors, breast carcinoma

Abstract

Background: Breast carcinoma is the most common malignant tumour and leading cause of cancer death among women worldwide. VEGF being a powerful mediator of angiogenesis, plays a major role in local growth as well as metastasis of many solid tumours including breast carcinoma.

Objective: This study aimed to evaluate the significance of VEGF expression in breast cancer and its correlation with prognostic parameters. Materials and methods: This study was conducted over a period of one year (February 2015 to January 2016). VEGF expression was evaluated in 57 histologically diagnosed cases of breast carcinoma with known ER and HER-2/neu status.

Result: Among 57 cases 52(91.2%) were positive for VEGF. Positive ER expression was seen in 39 cases which is 64.8% of total cases. 54% of the total cases were positive for HER-2/neu. VEGF expression was positively correlated (P value <0.05) with tumour grade, tumour size and negatively correlated with ER (p<0.005) and HER-2/neu (p<0.005). Significant correlation also found with tumour type (p<.005).

Conclusion: Considering the observations of the current study, it can be concluded that VEGF may play a crucial role in the pathogenesis of breast carcinoma and has a positive correlation with biologically aggressive tumour. So consideration of this biomarker (VEGF) is to be regarded as a prognostic parameter and critical evaluator of targeted chemotherapy

Bangladesh Journal of Medical Science Vol.18(3) 2019 p.513-518

Downloads

Download data is not yet available.
Abstract
26
PDF
55

Downloads

Published

2019-05-30

How to Cite

Nandi, J., Maiti, M., Barman, N., Paul, M., Medda, S., Ghosal, S. R., & Sarkar, R. (2019). Correlation of VEGF expression with prognostic factors of breast carcinoma. Bangladesh Journal of Medical Science, 18(3), 513–518. https://doi.org/10.3329/bjms.v18i3.41619

Issue

Vol. 18 No. 3 (2019)

Section

Original Articles

License

Authors who publish in the Bangladesh Journal of Medical Science agree to the following terms that:

  1. Authors retain copyright and grant Bangladesh Journal of Medical Science the right of first publication of the work.

  2. Creative Commons Licence
    Articles in Bangladesh Journal of Medical Science are licensed under a Creative Commons Attribution 4.0 International License CC BY-4.0.This license permits use, distribution and reproduction in any medium, provided the original work is properly cited.
  3. Authors are able to enter into separate, additional contractual arrangements for the distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  4. Authors are permitted to post their work online (e.g., in institutional repositories or on their website) as it can lead to productive exchanges, as well as greater citation of published work.