The Low umbilical cord Zinc levels Lead to Atopic Allergic Infants : a Cohort study during 0-4 months of Age

Authors

  • Sri Priyantini Departement of Pediatrics, Faculty of Medicine, Sultan Agung Islamic University, Semarang, Indonesia
  • - Suprihati Departement of Otolaryngology-Head and Neck Surgery, Faculty of Medicine Diponegoro University, Semarang, Indonesia
  • Nyoman Suci Widyastiti Department of Clinical Pathology, Faculty of Medicine, Diponegoro University Diponegoro University, Semarang, Indonesia
  • - Soemantri Departement of Pediatrics, Faculty of Medicine, Diponegoro University Diponegoro University, Semarang, Indonesia

DOI:

https://doi.org/10.3329/bjms.v19i1.43883

Keywords:

umbilical cord zinc levels; atopic allergy; very early formula feeding

Abstract

Background: The research on association between differentiation of Th1 and Th2 were previously conducted on experimental animals. The study on association between umbilical cord zinc and the risk of allergy symptoms during early stage of life has not been conducted in Indonesia. Studies on zinc and allergies are commonly investigated during adulthood and the results are still contradictive.

Objective: The aim of the study is to determine the extent of zinc’s role in the emergence of atopic allergy symptoms during the first 4 months age

Methods: This prospective cohort study includes consecutive 80 healthy newborns followed up for 4 months after birth at Semarang Sultan Agung Islamic Hospital and Bangetayu Primary Health Care. Hypothesis testing were analyzed with unpaired t-test , chi-square test or fisher’s test

Results: The mean value of cord blood zinc in allergic infants were significantly lower when compared with non atopic allergy (74.1 ± 17.3 μg / dL vs 91.5 ± 22.6 μg / dL, p=0.029). Very early formula feeding were 4.4 times more at risk of suffering from allergies(p=0.023).

Conclusion: Umbilical cord zinc levels are associated with atopic allergy symptoms for the first 4 months of life. Formula feeding before 1 month of age was associated with atopic allergic infants

Bangladesh Journal of Medical Science Vol.19(1) 2020 p.114-121

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Published

2019-11-03

How to Cite

Priyantini, S., Suprihati, .-., Widyastiti, N. S., & Soemantri, .-. (2019). The Low umbilical cord Zinc levels Lead to Atopic Allergic Infants : a Cohort study during 0-4 months of Age. Bangladesh Journal of Medical Science, 19(1), 114–121. https://doi.org/10.3329/bjms.v19i1.43883

Issue

Vol. 19 No. 1 (2020)

Section

Original Articles

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