Prevalence of imipenem resistant gram-negative bacteria in a tertiary care hospital of Dhaka, Bangladesh

Authors

  • Rabeya Nahar Ferdous Department of Microbiology, Bangladesh University of Health Sciences, Bangladesh
  • Md Atikur Rahman Institute of Microbiology, Friedrich-Schiller-University Jena, Germany
  • Md Anowar Hussain Department of Community Dentistry, Bangladesh University of Health Sciences, Bangladesh
  • Nasrin Akhter Department of Pharmaceuticals Sciences, North South University, Bangladesh
  • Palash Chandra Banik Department of Non-Communicable Disease, Bangladesh University of Health Sciences, Bangladesh
  • Mohammad Mahmudur Rahman Department of Medical Biotechnology, Bangladesh University of Health Sciences, Bangladesh

DOI:

https://doi.org/10.3329/bjms.v21i1.56341

Keywords:

Imipenem resistance; multidrug-resistance; tertiary care hospital; gram-negative bacteria (GNB); Bangladesh

Abstract

Objective: Imipenem resistant gram-negative bacteria (GNB) have become a major public health concern worldwide, including Bangladesh. The present study was performed to determine the frequency of imipenem resistant gram-negative bacteria (GNB), their antimicrobial susceptibility pattern.

Materials and Methods: A total of three hundred and fifty clinical samples were collected from Bangladesh Institute of Health Sciences hospital (BIHS), Dhaka, Bangladesh, over a period of 12 months. Among 350 samples, 171 (48.86%) were from indoor patients, and 179 (51.14%) were from outdoor patients. The pathogens were isolated and identified by conventional methods and were screened for antibiotic susceptibility using the Kirby–Bauer disc diffusion method, including imipenem discs. A Chi-square test was employed for statistical analysis.

Results and Discussion: Out of 350 clinical isolates, 246 showed resistance to imipenem (70.28%). Almost all of the imipenem resistant gram-negative bacteria showed the highest resistant pattern to cefepime (88.57%), amoxicillin (88.29%), cephalosporin (88.14%), cefoxitin (86%), tetracycline (84.42%), and the majority were resistant to levofloxacin (70.85%), doxycycline (70.57%), netilmicin (59.71%). But cotrimoxazole (13.42%) and tigecycline (11.43%) showed a lower resistance pattern. Statistical analysis exhibited imipenem resistant gram-negative isolates most commonly found in pus and urine samples, while Klebsiella spp (30.49%), Pseudomonas spp (26.83%) and E. coli (23.17%) were the most predominant pathogens.

Conclusion: This is a retrospective study which study indicates a noteworthy rate of clinical isolates were imipenem resistant gram-negative bacteria in a well-defined tertiary care hospital, and most of these bacteria were also multidrug-resistant.

Bangladesh Journal of Medical Science Vol. 21(1) 2022 Page : 145-150

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Published

2022-01-01

How to Cite

Ferdous, R. N. ., Rahman, M. A. ., Hussain, M. A. ., Akhter, N. ., Banik, P. C. ., & Rahman, M. M. . (2022). Prevalence of imipenem resistant gram-negative bacteria in a tertiary care hospital of Dhaka, Bangladesh. Bangladesh Journal of Medical Science, 21(1), 145–150. https://doi.org/10.3329/bjms.v21i1.56341

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Original Articles