A Clinical-Based Drug Interaction Alert (CIDIA) System for Preventing Drug Interaction and Its Associated Factors at Rural Primary Care Centres

Authors

  • Flori R Sari Department of Pharmacology, Faculty of Medicine Universitas Islam Negeri Syarif Hidayatullah, Jalan Kertamukti No. 5, Banten, Indonesia
  • Saiful Anwar Post-Graduate Program, Institut Teknologi dan Bisnis Ahmad Dahlan, Banter, Indonesia
  • - Risahmawati Department of Community Medicine, Faculty of Medicine Universitas Islam Negeri Syarif Hidayatullah, Jalan Kertamukti No. 5, Banten, Indonesia
  • Marita Fadhilah Department of Community Medicine, Faculty of Medicine Universitas Islam Negeri Syarif Hidayatullah, Jalan Kertamukti No. 5, Banten, Indonesia
  • Fika Ekayanti Department of Community Medicine, Faculty of Medicine Universitas Islam Negeri Syarif Hidayatullah, Jalan Kertamukti No. 5, Banten, Indonesia

DOI:

https://doi.org/10.3329/bjms.v22i3.66962

Keywords:

drug interactions; female; patients; prescriptions; primary health care

Abstract

Objectives: Drug-drug interaction (DDI) occurs following the prescription of more than one drug. DDI and its associated factors in Indonesia’s country’s primary care have not been reported.

Materials and Methods: Through this descriptive cross-sectional study, we analysed the DDI incidence using the Clinical-Based Drug Interaction Alert (CIDIA) alert system. Purposive research was carried out by analysing prescriptions (n=2410) from nine primary health cares.

Results: CIDIA alert system detected 7.5% DDI incidence in all prescriptions, categorized as mild (63%), moderate (36%) and serious (1%). Significant DDI incidence was observed in female patients (p<0.01), in patients older than 18 years (p<0.01) and in patients receiving three or more drugs (p<0.01). The most frequent incidence of DDI from each category was paracetamol-domperidone; dexamethasone-mefenamic acid and captopril-allopurinol.

Conclusion: CIDIA alert system has been shown to provide beneficial support in detecting DDI incidence. Careful consideration should be addressed particularly towards female patients, older patients, and patients receiving three or more drugs in preventing DDI incidence.

Bangladesh Journal of Medical Science Vol. 22 No. 03 July’23 Page : 667-675

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Published

2023-06-16

How to Cite

Sari, F. R., Anwar, S., Risahmawati, .-., Fadhilah, M. ., & Ekayanti, F. . (2023). A Clinical-Based Drug Interaction Alert (CIDIA) System for Preventing Drug Interaction and Its Associated Factors at Rural Primary Care Centres. Bangladesh Journal of Medical Science, 22(3), 667–675. https://doi.org/10.3329/bjms.v22i3.66962

Issue

Vol. 22 No. 3 (2023)

Section

Original Articles

License

Copyright (c) 2023 Flori R Sari, Saiful Anwar, - Risahmawati, Marita Fadhilah, Fika Ekayanti

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