Association between Serum C-peptide Level and Diabetic Nephropathy in Type 2 Diabetes Mellitus Patients on Oral Anti-diabetic Drug

Authors

  • Adhir Kumar Das Professor and Head of Pharmacology department, Dhaka Medical College, Dhaka, Bangladesh
  • Rumana Tasnim Postgraduate student, Department of Pharmacology, Dhaka Medical College, Dhaka, Bangladesh
  • Jahidul Islam Assistant Professor, Department of Pharmacology, UCSI University, Springhill, Port Dickson, Malaysia

DOI:

https://doi.org/10.3329/bjms.v22i4.67106

Keywords:

C-peptide; Diabetic Nephropathy (DN); Oral Anti-diabetic drugs

Abstract

Background: Diabetic Nephropathy (DN) treatment focuses mostly on preventing or delaying disease development. The most recent research indicates that C-peptide may have a favourable biological effect on DN. In type 2 Diabetes Mellitus, the link between C-peptide level and DN is poorly understood (DM). The purpose of this study is to evaluate the relation between serum C-peptide and diabetic nephropathy in type 2 DM patients taking an oral anti diabetic medication.

Methods: From July 2019 to June 2020, a cross-sectional observational study was done at the Department of Pharmacology and Therapeutics at Dhaka Medical College, Dhaka. A total of 63 randomly selected type 2 diabetes patients met the inclusion criteria. SPSS was used to collect, record, and evaluate biochemical values including FBG, 2hrs ABF, HbA1c, urine for microalbumin, serum creatinine, and serum C-peptide.

Result: Among 63 study participants, 40 (63.5%) were female and 23 (36.5%) were male. Mean age of patients was 50.30±10.55 years. Mean duration of DM of total study subjects was 6.29±3.15 years. Out of total study subjects, 17.5% (11) had low serum C-peptide, 74.6% (47) had normal serum C-peptide and 7.9% (5) had high serum C-peptide level. Correlations of clinical and biochemical variables showed negative correlation between serum C-peptide level and microalbumin, DM duration, FBS, 2hrs ABF, HbA1c, creatinine. Mean urine albumin was higher in patients with low serum C-peptide level. The microalbumin level and the duration of DM of study subjects are significantly associated with serum C-peptide.

Conclusion: In this study we have found that type 2 diabetic individuals with low serum C-peptide levels have a high frequency of diabetic nephropathy and that serum C-peptide levels are significantly associated with diabetic nephropathy.

Bangladesh Journal of Medical Science Vol. 22 No. 04 October’23 Page : 768-772

Downloads

Download data is not yet available.
Abstract
24
PDF
66

Downloads

Published

2023-09-07

How to Cite

Das, A. K. ., Tasnim, R. ., & Islam, J. . (2023). Association between Serum C-peptide Level and Diabetic Nephropathy in Type 2 Diabetes Mellitus Patients on Oral Anti-diabetic Drug. Bangladesh Journal of Medical Science, 22(4), 768–772. https://doi.org/10.3329/bjms.v22i4.67106

Issue

Vol. 22 No. 4 (2023)

Section

Original Articles

License

Copyright (c) 2023 Adhir Kumar Das, Rumana Tasnim, Jahidul Islam

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish in the Bangladesh Journal of Medical Science agree to the following terms that:

  1. Authors retain copyright and grant Bangladesh Journal of Medical Science the right of first publication of the work.

  2. Creative Commons Licence
    Articles in Bangladesh Journal of Medical Science are licensed under a Creative Commons Attribution 4.0 International License CC BY-4.0.This license permits use, distribution and reproduction in any medium, provided the original work is properly cited.
  3. Authors are able to enter into separate, additional contractual arrangements for the distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  4. Authors are permitted to post their work online (e.g., in institutional repositories or on their website) as it can lead to productive exchanges, as well as greater citation of published work.