Drug delivery behavior of magnetic composite: In vitro study

Authors

  • Birnur Akkaya Cumhuriyet University, Science Faculty, Molecular Biology and Genetics Department, Sivas/Turkey
  • Beyza Nur Yerliyurt Cumhuriyet University, Science Faculty, Molecular Biology and Genetics Department, Sivas/Turkey

DOI:

https://doi.org/10.3329/bjms.v23i3.75022

Keywords:

Composite; drug release; magnetic field; expanded perlite.

Abstract

Background One method for delivering the medication to the intended location and achieving the desired therapeutic effect is controlled drug release. Compared to typical release systems, controlled medication release systems offer fewer potential adverse effects and can increase patient comfort by prolonging the time intervals between drug intakes. Expanded perlite modified composite were used as drug carrier materials in the current investigation because of its excellent adsorption capability.

Aim: Using magnetic poly(hydroxyethylmethacrylate-expanded perlite) (m-p(hema-ep)) composite material, doxorubicin release was examined in this work.

Methodolgy First, a magnetic p(hema-ep) composite was created for this purpose and examined using SEM, FTIR, and swelling tests. The medication doxorubicin served as a model. Tests for reusability were conducted. The synthesized magnetic p(hema-ep) composite was shown to be capable of being recycled ten times without losing effectiveness. On the C6 cell line, the material and the material that had been loaded with doxorubicin were subjected to cytotoxicity tests under magnetic field.

Results The impacts of variables like pH, time, temperature, on drug release were examined as a consequence of the characterisation procedure. The ideal release parameters were found to be 80% release at pH 4.5, 70% release is seen at 7.4, and temperature 22 °C, under magnetic field.

Conclusion: The anti-cancer medication doxorubicin (Dox) was used as a model drug because it is widely used in cancer treatment and is simple to quantify using methods like UV-visible spectroscopy. There are enhanced doxorubicin release under magnetic field.  

Bangladesh Journal of Medical Science Vol. 23 No. 03 July’24 Page : 666-675

Downloads

Download data is not yet available.
Abstract
49
PDF
38

Downloads

Published

2024-07-29

How to Cite

Akkaya, B., & Yerliyurt, B. N. (2024). Drug delivery behavior of magnetic composite: In vitro study. Bangladesh Journal of Medical Science, 23(3), 666–675. https://doi.org/10.3329/bjms.v23i3.75022

Issue

Vol. 23 No. 3 (2024)

Section

Original Articles

License

Copyright (c) 2024 Birnur Akkaya, Beyza Nur Yerliyurt

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish in the Bangladesh Journal of Medical Science agree to the following terms that:

  1. Authors retain copyright and grant Bangladesh Journal of Medical Science the right of first publication of the work.

  2. Creative Commons Licence
    Articles in Bangladesh Journal of Medical Science are licensed under a Creative Commons Attribution 4.0 International License CC BY-4.0.This license permits use, distribution and reproduction in any medium, provided the original work is properly cited.
  3. Authors are able to enter into separate, additional contractual arrangements for the distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  4. Authors are permitted to post their work online (e.g., in institutional repositories or on their website) as it can lead to productive exchanges, as well as greater citation of published work.