Correlation between Bone Scan Findings and CA 153 in Patients with Carcinoma Breast

Authors

  • Samira Sharmin Senior Medical Officer, Institute of Nuclear Medicine and Allied Sciences, Sir Salimullah Medical College campus, Mitford, Dhaka
  • Jasmine Ara Haque National Institute of Nuclear Medicine and Allied Sciences, Dhaka
  • Md Mahbub ur Rahman Institute of Nuclear Medicine and Allied Sciences, Mitford, Dhaka
  • Hosne Ara Rahman Institute of Nuclear Medicine and Allied Sciences, Mitford, Dhaka
  • Jamiul Hossain Institute of Nuclear Medicine and Allied Sciences, Mitford, Dhaka
  • Md Monir Uddin Radiology and Imaging, Bangabandhu Sheikh Mujib Medical University, Dhaka
  • Jesmine Ferdous Institute of Nuclear Medicine and Allied Sciences, Mitford, Dhaka
  • Farida Yasmin Institute of Nuclear Medicine and Allied Sciences, Mitford, Dhaka

DOI:

https://doi.org/10.3329/bjnm.v20i1.36850

Keywords:

Bone scan, Carcinoma Breast, CA 15-3 level

Abstract

Objectives: Breast carcinoma is the most life threatening malignant condition in women. This malignant disease commonly metastasizes to bone. Carbohydrate antigen (CA) 15-3 is a circulating human breast cancer associated antigen used as a tumor marker in the screening of breast cancer patients for metastasis. The objective of this study was to compare the levels of CA 15-3 and bone scan findings in patients with breast cancer.

Patients and Methods: This cross sectional study was carried out at Institute of Nuclear Medicine and Allied sciences, Mitford, Dhaka, from January 2015 to December 2015. A total of 75 diagnosed breast cancer patients were enrolled in this study. All of them underwent bone scan. The tumor maker CA 15-3 was compared with bone scan findings. Pearson’s correlation coefficient test was done to see the relationship between bone scan and CA 15-3.

Results: Mean age of the patients was 47.60 ± 10.53 years (range 25 to 65 years). About half (49%) of the patients belong to the age group 50 years and above. Mean ± SD of CA 15-3 was 84.06 ± 104.60 U/ml (range from 10.12 to 395.30 U/ml). Out of 75 patients, 33 patients showed elevated CA 15-3 level, among them 42% had negative bone scan with mean ± SD CA 15-3 level 60.98 ± 9.95 U/ml (range 40.26-72.17 U/ml), 58% patients had positive bone scan with mean ± SD CA 15-3 level 246.23 ± 81.35U/ml (range 110-395.30 U/ml). CA 15-3 was within normal limit (range 10.20-30.10 U/ml) in 42 patients. Among them 29% patients had negative bone scan and 71% patients had positive bone scan. Pearson’s correlation coefficient test showed positive relationship (p = 0.001, r = 0.343) between CA 15-3 level and bone scan findings.

Conclusion: The result of the study showed positive relationship between the bone scan findings and CA 15-3 level of carcinoma breast patients.

Bangladesh J. Nuclear Med. 20(1): 24-26, January 2017

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Published

2018-06-07

How to Cite

Sharmin, S., Haque, J. A., Rahman, M. M. ur, Rahman, H. A., Hossain, J., Uddin, M. M., Ferdous, J., & Yasmin, F. (2018). Correlation between Bone Scan Findings and CA 153 in Patients with Carcinoma Breast. Bangladesh Journal of Nuclear Medicine, 20(1), 24–26. https://doi.org/10.3329/bjnm.v20i1.36850

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Original Articles