Correlation of Pre-Operative Myo-Inositol/Creatine Ratio with Histopathological Grade of Glioma

Abstract

Background: Introduction: Gliomas are the most frequent primary intracerebral tumors in adults & constitute 35–50% of all intracranial neoplasms. In determining a treatment plan, tumor grade is a key consideration for minimizing the risk of unnecessary morbidity and mortality. Objective: To evaluate Correlation of pre-operative Myo-inositol/Creatine ratio with histopathological grade of glioma. Materials and method: This was a cross sectional experimental study. Total 33 patients consistent with selection criteria were enrolled in this study. Myo-inositol/ Creatine ratio was obtained from MRS. Histopathological grade of glioma was obtained from biopsy (hematoxylin and eosin stain or HE stain) report. The obtained results were then grouped categorically. Result: Out of 33 patients, 22 were male and 11 were female. According to histopathology, 14 gliomas were confirmed as high grade and 19 gliomas were confirmed as low grade. Spearman Rank Correlation Test showed a moderate negative association between Myo-inositol/Creatine ratio with glioma grading with coefficient value of r = -0.611 with a statistically significant p-value (p<0.001). We were able to differentiate between low grade (II) and high grade (III + IV) gliomas using the Myoinositol/ Creatine ratio. The levels of MI/Cr were higher (e”0.48) in patients with lowgrade glioma, and lower (<0.48) in patients high grade glioma Conclusion: This study has shown a significant correlation between pre-operative Myo-inositol/Creatine ratio with histopathological grade of glioma. It may help neurosurgeons in taking clinical decisions about patient management and counselling.

Bang. J Neurosurgery 2024; 13(2): 57-63